Episode
PETAL Consortium Survival Prognosticators and How Inflammation Impacts Hematopoiesis
- Podcast
- Blood Podcast
- Published
- Mar 5, 2026
- Duration seconds
- 780
- Processing state
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- https://share.transistor.fm/s/65259fd5
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Summary
In this week's episode, Blood associate editor Dr. Laura Michaelis interviews Drs. Mark Sorial and Emmanuelle Passegue on their articles published in volume 147 issue 7 of Blood . Dr. Sorial discusses " Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium " where he and his team evaluated the prognostic significance of early relapse in a large retrospective cohort. They report a time to relapse of <12 months as a strong predictive factor independent of the prognostic index for T-cell lymphoma and histology, with results validated in 2 independent cohorts. Dr. Emmanuelle Passegue discusses " Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche ". Using a combination of single-cell RNA sequencing profiling and flow cytometry, the team characterized the bone marrow niche compartments in mice subjected to inflammation. They show that inter-feron-mediated inflammation preferentially targets central marrow leptin receptor–expressing mesenchymal cells, triggering cytokine release that affects monocyte dynamics in the bone marrow microenvironment.