# PETAL Consortium Survival Prognosticators and How Inflammation Impacts Hematopoiesis

Page: https://stenobird.com/podcast/blood-podcast-664776/petal-consortium-survival-prognosticators-and-how-inflammation-impacts-hematopoiesis
Text version: https://stenobird.com/podcast/blood-podcast-664776/petal-consortium-survival-prognosticators-and-how-inflammation-impacts-hematopoiesis.md
Podcast: [Blood Podcast](https://stenobird.com/podcast/blood-podcast-664776)
Published: 2026-03-05T17:00:00+00:00
Episode link: https://share.transistor.fm/s/65259fd5
Audio file: https://prfx.byspotify.com/e/media.transistor.fm/65259fd5/7a73e32c.mp3
Processing state: not_requested
JSON: https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/petal-consortium-survival-prognosticators-and-how-inflammation-impacts-hematopoiesis
Duration seconds: 780

## Resource

In this week's episode, Blood associate editor Dr. Laura Michaelis interviews Drs. Mark Sorial and Emmanuelle Passegue on their articles published in volume 147 issue 7 of Blood . Dr. Sorial discusses " Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium " where he and his team evaluated the prognostic significance of early relapse in a large retrospective cohort. They report a time to relapse of <12 months as a strong predictive factor independent of the prognostic index for T-cell lymphoma and histology, with results validated in 2 independent cohorts. Dr. Emmanuelle Passegue discusses " Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche ". Using a combination of single-cell RNA sequencing profiling and flow cytometry, the team characterized the bone marrow niche compartments in mice subjected to inflammation. They show that inter-feron-mediated inflammation preferentially targets central marrow leptin receptor–expressing mesenchymal cells, triggering cytokine release that affects monocyte dynamics in the bone marrow microenvironment.

## Actions

- request_transcript: `POST https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/petal-consortium-survival-prognosticators-and-how-inflammation-impacts-hematopoiesis/transcription-requests` — Idempotently request low-priority transcript generation for this episode.
- read_markdown: `GET https://stenobird.com/podcast/blood-podcast-664776/petal-consortium-survival-prognosticators-and-how-inflammation-impacts-hematopoiesis.md` — Read the agent-friendly Markdown representation of this episode resource.

A page view does not enqueue transcription. Agents should invoke `request_transcript` explicitly when they need this episode processed.

## Transcript

Full transcripts are not published on public pages unless there is a clear rights basis.