Episode
CAR-iNKT cell immunotherapy and Jagged2/Notch regulation of HSC
- Podcast
- Blood Podcast
- Published
- Feb 12, 2026
- Duration seconds
- 1210
- Processing state
not_requested- Canonical source
- https://share.transistor.fm/s/a342d949
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Summary
In this week's episode, Blood editor Dr. Laurie Sehn interviews authors Drs. Anastasios Karadimitris and Maria Carolina Florian on their papers published in Volume 147 Issue 2 of Blood . Dr. Karadimitris' paper " Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A -rearranged leukemia ", discusses the success of bispecific CAR-iNKT cells targeting CD19 and CD133 in pre-clinical models, prompting the clinical development of this class of product. Dr. Florian's paper, " A Notch trans -activation to cis -inhibition switch underlies hematopoietic stem cell aging " proposes that the Jagged2/Notch interaction is a key regulator of hematopoietic stem cell divisional symmetry during aging and offers insights that may inform strategies to restore regenerative function in aged hematopoiesis.