# CAR-iNKT cell immunotherapy and Jagged2/Notch regulation of HSC

Page: https://stenobird.com/podcast/blood-podcast-664776/car-inkt-cell-immunotherapy-and-jagged2-notch-regulation-of-hsc
Text version: https://stenobird.com/podcast/blood-podcast-664776/car-inkt-cell-immunotherapy-and-jagged2-notch-regulation-of-hsc.md
Podcast: [Blood Podcast](https://stenobird.com/podcast/blood-podcast-664776)
Published: 2026-02-12T18:43:14+00:00
Episode link: https://share.transistor.fm/s/a342d949
Audio file: https://prfx.byspotify.com/e/media.transistor.fm/a342d949/01365364.mp3
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JSON: https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/car-inkt-cell-immunotherapy-and-jagged2-notch-regulation-of-hsc
Duration seconds: 1210

## Resource

In this week's episode, Blood editor Dr. Laurie Sehn interviews authors Drs. Anastasios Karadimitris and Maria Carolina Florian on their papers published in Volume 147 Issue 2 of Blood . Dr. Karadimitris' paper " Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A -rearranged leukemia ", discusses the success of bispecific CAR-iNKT cells targeting CD19 and CD133 in pre-clinical models, prompting the clinical development of this class of product. Dr. Florian's paper, " A Notch trans -activation to cis -inhibition switch underlies hematopoietic stem cell aging " proposes that the Jagged2/Notch interaction is a key regulator of hematopoietic stem cell divisional symmetry during aging and offers insights that may inform strategies to restore regenerative function in aged hematopoiesis.

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## Transcript

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