{"podcast":{"title":"Blood Podcast","slug":"blood-podcast-664776","podcast_index_feed_id":664776,"rss_url":"https://feeds.transistor.fm/blood-podcast","website_url":null,"image_url":"https://img.transistorcdn.com/WlMZsA1edpS0qEIavlrh9KLfCFShKE7FTJxZLlZsByw/rs:fill:0:0:1/w:1400/h:1400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9kY2Q4/YzJhZmMwODBjOWRi/YTNhN2Y1NWJkMzMw/NTBjZi5qcGc.jpg","author":"American Society of Hematology","episode_count":388,"summary":"The Blood Podcast summarizes content recently published in Blood, the most cited peer-reviewed publication in the field of hematology.","last_synced_at":"2026-07-17T04:20:44.828596+00:00","page_url":"https://stenobird.com/podcast/blood-podcast-664776"},"episode":{"title":"CAR-iNKT cell immunotherapy and Jagged2/Notch regulation of HSC","slug":"car-inkt-cell-immunotherapy-and-jagged2-notch-regulation-of-hsc","published_at":"2026-02-12T18:43:14+00:00","page_url":"https://stenobird.com/podcast/blood-podcast-664776/car-inkt-cell-immunotherapy-and-jagged2-notch-regulation-of-hsc","show_page_url":"https://stenobird.com/podcast/blood-podcast-664776","url":"https://share.transistor.fm/s/a342d949","audio_url":"https://prfx.byspotify.com/e/media.transistor.fm/a342d949/01365364.mp3","summary":"In this week's episode, Blood editor Dr. Laurie Sehn interviews authors Drs. Anastasios Karadimitris and Maria Carolina Florian on their papers published in Volume 147 Issue 2 of Blood . Dr. Karadimitris' paper \" Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A -rearranged leukemia \", discusses the success of bispecific CAR-iNKT cells targeting CD19 and CD133 in pre-clinical models, prompting the clinical development of this class of product. Dr. Florian's paper, \" A Notch trans -activation to cis -inhibition switch underlies hematopoietic stem cell aging \" proposes that the Jagged2/Notch interaction is a key regulator of hematopoietic stem cell divisional symmetry during aging and offers insights that may inform strategies to restore regenerative function in aged hematopoiesis.","meta_description":"In this week's episode, Blood editor Dr. Laurie Sehn interviews authors Drs. Anastasios Karadimitris and Maria Carolina Florian on their papers published…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1210,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/car-inkt-cell-immunotherapy-and-jagged2-notch-regulation-of-hsc/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/blood-podcast-664776/car-inkt-cell-immunotherapy-and-jagged2-notch-regulation-of-hsc.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}