Episode
Should you take Ozempic? The 5 things you need to know before starting GLP-1 drugs | Dr Ania Jastreboff
- Podcast
- ZOE Science & Nutrition
- Published
- Apr 30, 2026
- Duration seconds
- 3705
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Summary
GLP-1 drugs like Ozempic and Mounjaro are now everywhere. But what do they actually do beyond weight loss? And what do you need to know before starting them? In this episode, we’re joined by Dr Ania Jastreboff, a world-leading researcher at the forefront of GLP-1 treatments and writer of the New York Times bestselling book Enough: Your Health, Your Weight, and What It's Like To Be Free, co-authored with Oprah Winfrey. Dr Jastreboff explains everything you need to know about Ozempic, Mounjaro, Wegovy and other GLP-1 medications for 2026. You’ll learn how GLP-1s may reduce the risk of heart disease, improve blood sugar control, and support conditions like sleep apnoea. We also explore why weight often returns after stopping, and what you need to know about Ozempic side effects and long-term use. If these drugs can change how your brain controls hunger, what does that mean for willpower, weight gain, and how we treat obesity long term? 🌱 Try our science-backed and tasty wholefood supplement Daily30 Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE Follow ZOE on Instagram. Timecodes 00:00 Intro 04:25 What these drugs are really treating 06:42 The hunger problem nobody could name 10:57 The diabetes side effect that changed everything 12:15 Why Ozempic isn’t just “more GLP-1” 15:51 Why Mounjaro works differently to Ozempic 17:56 The part everyone gets wrong 20:15 Can these drugs protect your heart? 21:25 The 94% diabetes finding 22:09 Why the weight can come back 23:50 Do you have to take them forever? 25:30 Can you trust pharma-funded trials? 27:46 The risk of microdosing GLP-1s 31:41 Are these drugs becoming surgery-level? 34:10 The health effects beyond weight loss 37:22 The si…