Episode
Thiamin and Folic Acid for Cognitive Impairment in Hemodialysis Patients
- Podcast
- Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology
- Published
- May 2, 2026
- Duration seconds
- 827
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Summary
This clinical trial investigated the efficacy and safety of a combined vitamin B treatment for patients with cognitive impairment undergoing maintenance hemodialysis. Researchers conducted a prospective, double-blind study where 215 participants received either a daily dose of thiamin and folic acid or a placebo for nearly two years. The results showed that the treatment group experienced significant cognitive improvement across multiple domains, including memory and executive function, alongside a notable reduction in homocysteine levels . Furthermore, while mortality rates remained comparable between the two groups, those receiving supplements reported a significantly lower incidence of cardiovascular and cerebrovascular adverse events. The study concludes that high-dose thiamin and folic acid supplementation is a safe and effective therapy for addressing neurological complications in dialysis patients.