# Thiamin and Folic Acid for Cognitive Impairment in Hemodialysis Patients

Page: https://stenobird.com/podcast/weekly-neurology-deep-dive-a-review-of-recent-impactful-publications-in-the-field-of-neurology-7345980/thiamin-and-folic-acid-for-cognitive-impairment-in-hemodialysis-patients
Text version: https://stenobird.com/podcast/weekly-neurology-deep-dive-a-review-of-recent-impactful-publications-in-the-field-of-neurology-7345980/thiamin-and-folic-acid-for-cognitive-impairment-in-hemodialysis-patients.md
Podcast: [Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology](https://stenobird.com/podcast/weekly-neurology-deep-dive-a-review-of-recent-impactful-publications-in-the-field-of-neurology-7345980)
Published: 2026-05-02T19:30:26+00:00
Episode link: https://podcasters.spotify.com/pod/show/amer-ghavanini/episodes/Thiamin-and-Folic-Acid-for-Cognitive-Impairment-in-Hemodialysis-Patients-e3ipt9q
Audio file: https://anchor.fm/s/ff5a3958/podcast/play/119386874/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2026-4-2%2Fe4642a81-7487-b428-bdf0-b708fe482a75.m4a
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Duration seconds: 827

## Resource

This clinical trial investigated the efficacy and safety of a combined vitamin B treatment for patients with cognitive impairment undergoing maintenance hemodialysis. Researchers conducted a prospective, double-blind study where 215 participants received either a daily dose of thiamin and folic acid or a placebo for nearly two years. The results showed that the treatment group experienced significant cognitive improvement across multiple domains, including memory and executive function, alongside a notable reduction in homocysteine levels . Furthermore, while mortality rates remained comparable between the two groups, those receiving supplements reported a significantly lower incidence of cardiovascular and cerebrovascular adverse events. The study concludes that high-dose thiamin and folic acid supplementation is a safe and effective therapy for addressing neurological complications in dialysis patients.

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