Episode
uniQure Staggers at FDA, Recursion's Microglia Map, and Leadership Transitions
- Podcast
- Touching Base
- Published
- Nov 7, 2025
- Duration seconds
- 1894
- Processing state
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- https://shows.acast.com/touching-base/episodes/uniqure-staggers-at-fda-recursions-microglia-map-and-leaders
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Summary
uniQure's “game changing” data announced in September, which showed significant slowing of Huntington’s disease (HD) progression in patients treated with its gene therapy candidate AMT-130, may not be enough to secure FDA approval. We also discuss Recursion's pivotal leadership transitions, as Najat Khan, PhD, chief R&D officer and chief commercial officer, is set to take over as the company's CEO effective January 1. The AI drug developer has made big bets filling the biology data gap and recently announced a "Google Map of the brain" to advance neurodegenerative disease targets. In open-source AI for drug discovery, the release of the latest Boltz model, BoltzGen, advances the platform from structural predictions to the design of "any" therapeutic modality, all available for commercial use. Join GEN editors Corinna Singleman, PhD, Alex Philippidis, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news. Listed below are links to the GEN stories referenced in this episode of Touching Base : uniQure Staggers as FDA Questions Data for Huntington’s Gene Therapy Candidate By Alex Philippidis, GEN Edge , November 3, 2025 StockWatch: uniQure Shares Reach Five-Year High on “Game Changing” Huntington’s Data Alex Philippidis , GEN Edge, September 28, 2025 Gene Therapy Significantly Slows Huntington Disease Progression GEN, September 24, 2025 Recursion, Roche Unveil Microglia Map of Neuro Disease Targets By Alex Philippidis, GEN Edge , October 29, 2025 BoltzGen Democratizes AI Therapeutic Design, Expands Druggable Universe By Fay Lin, PhD, GEN , October 27, 2025 The State of AI in Drug Discovery On Dem…