{"podcast":{"title":"Touching Base","slug":"touching-base-6714887","podcast_index_feed_id":6714887,"rss_url":"https://feeds.acast.com/public/shows/65736d39d32e730012c98919","website_url":"https://shows.acast.com/65736d39d32e730012c98919","image_url":"https://assets.pippa.io/shows/cover/1702062363830-62d389f5db6a973569dc75512134cd32.jpeg","author":"Genetic Engineering & Biotechnology News (GEN)","episode_count":55,"summary":"Touching Base is the dynamic podcast series from the editors of GEN ( Genetic Engineering & Biotechnology News ). Each episode features a rotating cast of senior editors including John Sterling, Kevin Davies, Julianna LeMieux, Alex Philippidis, Uduak Thomas, Corinna Singleman and Fay Lin who delve into emerging stories, exchange ideas, and debate the latest trends in biotech. Additionally, they talk to some of the leading voices in the industry about what's now and next. Hosted on Acast. See acast.com/privacy for more information.","last_synced_at":"2026-08-01T02:20:08.667530+00:00","page_url":"https://stenobird.com/podcast/touching-base-6714887"},"episode":{"title":"uniQure Staggers at FDA, Recursion's Microglia Map, and Leadership Transitions","slug":"uniqure-staggers-at-fda-recursion-s-microglia-map-and-leadership-transitions","published_at":"2025-11-07T16:06:18+00:00","page_url":"https://stenobird.com/podcast/touching-base-6714887/uniqure-staggers-at-fda-recursion-s-microglia-map-and-leadership-transitions","show_page_url":"https://stenobird.com/podcast/touching-base-6714887","url":"https://shows.acast.com/touching-base/episodes/uniqure-staggers-at-fda-recursions-microglia-map-and-leaders","audio_url":"https://sphinx.acast.com/p/open/s/65736d39d32e730012c98919/e/690e0df36d62d4e03d70550d/media.mp3","summary":"uniQure's “game changing” data announced in September, which showed significant slowing of Huntington’s disease (HD) progression in patients treated with its gene therapy candidate AMT-130, may not be enough to secure FDA approval. We also discuss Recursion's pivotal leadership transitions, as Najat Khan, PhD, chief R&D officer and chief commercial officer, is set to take over as the company's CEO effective January 1. The AI drug developer has made big bets filling the biology data gap and recently announced a \"Google Map of the brain\" to advance neurodegenerative disease targets. In open-source AI for drug discovery, the release of the latest Boltz model, BoltzGen, advances the platform from structural predictions to the design of \"any\" therapeutic modality, all available for commercial use.    Join GEN editors Corinna Singleman, PhD, Alex Philippidis, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news.     Listed below are links to the GEN stories referenced in this episode of Touching Base :     uniQure Staggers as FDA Questions Data for Huntington’s Gene Therapy Candidate   By Alex Philippidis, GEN Edge , November 3, 2025    StockWatch: uniQure Shares Reach Five-Year High on “Game Changing” Huntington’s Data   Alex Philippidis , GEN Edge, September 28, 2025    Gene Therapy Significantly Slows Huntington Disease Progression   GEN, September 24, 2025    Recursion, Roche Unveil Microglia Map of Neuro Disease Targets   By Alex Philippidis, GEN Edge , October 29, 2025    BoltzGen Democratizes AI Therapeutic Design, Expands Druggable Universe   By Fay Lin, PhD, GEN , October 27, 2025    The State of AI in Drug Discovery On Dem…","meta_description":"uniQure's “game changing” data announced in September, which showed significant slowing of Huntington’s disease (HD) progression in patients treated with…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1894,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/touching-base-6714887/episodes/uniqure-staggers-at-fda-recursion-s-microglia-map-and-leadership-transitions/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/touching-base-6714887/uniqure-staggers-at-fda-recursion-s-microglia-map-and-leadership-transitions.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}