Episode
How to Build a Baseline and Understand Your Risk
- Published
- Apr 25, 2026
- Duration seconds
- 917
- Processing state
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Summary
For APOE4 carriers, knowing your risk is only useful if you know what to do with it. In this episode, Sarah walks through her path to developing a baseline, and discusses the labs that actually matter, fasting insulin, homocysteine, hs-CRP, Vitamin D etc. Sarah also discusses why standard functional medicine isn't specific enough for APOE4 biology, and how to interpret baseline data without losing your mind in the process. Whats in this episode: What APOE4 actually is, and what it isn't Why the "nothing you can do" frame is the most expensive mistake APOE4 carriers can make The research caveat problem: why so many studies don't apply to people like me How I built my first baseline with blood work and cognitive testing before changing anything Why I started with Parsley Health and then moved to Dale Bredesen's PreCODE program What my PreCODE report revealed across metabolic, inflammatory, and cognitive domains Why my cognitive scores required more context than just a number on a page (ADHD, breastfeeding, medication status) Three practical takeaways for anyone at the beginning of this journey Why exercise leads Season 1, even though it wasn't where I started Show Notes & References