Episode
#283 - Brain health explained: Insulin resistance, biomarkers, and Alzheimer’s risk | Dr. David Perlmutter & Mike Haney
- Podcast
- LEVELS – A Whole New Level
- Published
- Oct 9, 2025
- Duration seconds
- 4187
- Processing state
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Summary
Alzheimer’s and dementia aren’t just a matter of age or genetics. Increasing evidence shows that metabolic health—particularly insulin resistance—plays a key role in cognitive decline. In this episode of A Whole New Level , neurologist and bestselling author Dr. David Perlmutter joins Mike Haney to explore the links between brain health and metabolism. They discuss the role of insulin resistance and inflammation in Alzheimer’s disease, the biomarkers that can reveal risk decades before symptoms, and how lifestyle interventions can dramatically change your trajectory. Topics include: Key biomarkers for assessing brain health: fasting insulin, A1C, homocysteine Why targeting inflammation may matter more than targeting amyloid plaques The promise and limitations of GLP-1 medications for dementia and Parkinson’s Practical steps you can take now to protect long-term cognitive function Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl 🎙 What Dr. David Perlmutter & Mike Haney discuss: 4:12 — Why Alzheimer’s is now called “Type 3 diabetes” 9:45 — The role of inflammation in brain health 15:22 — Biomarkers that predict dementia risk decades early 22:31 — Why mainstream Alzheimer’s drugs fall short 29:17 — GLP-1s and brain health 36:44 — Lifestyle changes vs. pharmaceuticals 44:19 — Why homocysteine matters 53:02 — Sleep, circadian rhythm, and brain resilience 1:02:38 — Early warning signs you shouldn’t ignore 1:15:07 — The hopeful message Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. L…