Episode
Ep329: GLP-1 Isn’t Working? Here’s What’s Actually Going On with Curtis Gillespie Sayers
- Podcast
- Fit + Fueled Life Podcast
- Published
- Mar 16, 2026
- Duration seconds
- 2414
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Summary
In this episode, I’m back with Curtis Gillespie Sayers, and we dig into why GLP-1s don’t always work the way people hope, especially for women in their late 30s, 40s, and beyond. Curtis shares insights from years of working with clients in functional nutrition and explains how things like metabolic adaptation, hormone shifts, gut issues, chronic stress, and not-so-great nutrition can all get in the way of these medications doing their job. Plus, he offers insights and solutions to help your GLP-1 work better. Here’s what you’ll learn: - Why GLP-1 medications work for some people and not for others - The surprising reason many people hit a weight loss plateau on GLP-1s - What damaged GLP receptors have to do with stubborn weight loss - Why being in a chronic calorie deficit can actually make fat loss harder - The metabolic cascade that happens when cortisol rises and thyroid function drops - The overlooked role of digestion, stomach acid, and bile when using GLP medications - Why some people experience hair loss, gallbladder issues, or pancreatitis on GLPs - The real reason some people get more food noise and hunger while taking GLPs - Why microdosing GLPs may create better metabolic stability than large weekly doses - The surprising reason losing fat can increase your body’s toxic burden - What actually determines whether you can come off a GLP without regaining weight - The peptides Curtis prefers for metabolism support and fat loss (and the popular one he strongly dislikes) - The real story behind “plant peptides,” oral GLP drops, and supplements all over social media Subscribe: https://carrotsncake.substack.com Semaglutide: https://elliemd.com/microdose?bp=tinahaupert Tirzepatide: https://elliemd.com/microdose?bp=tinahaupert Retatrutide: https://ignitepeptides.com/p…