Episode
GLP-1s Gave Me the Ick: A Personal Metabolic Experiment
- Podcast
- Commune with Jeff Krasno
- Published
- Jul 25, 2026
- Duration seconds
- 1118
- Processing state
not_requested- Canonical source
- https://traffic.megaphone.fm/COMM6818616966.mp3
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Summary
Ten pounds in two weeks. No hunger. No craving for coffee or alcohol. This is Jeff’s personal, week-by-week account of starting tirzepatide (sold as Zepbound), tracked through blood sugar, cholesterol markers, and a noticeable dimming of everyday motivation and joy. What changed in the first two weeks: appetite, weight, and energy Tracking glucose, LDL, ApoB, and other metabolic markers with a CGM and blood panels Why alcohol and coffee stopped feeling rewarding The emerging link between GLP-1s, dopamine, and the brain's reward circuitry The trade-off between appetite control and a sense of vitality or spark This episode is for anyone weighing GLP-1s for themselves, or curious what the drugs are actually like beyond the headlines. This episode was made possible by: CocoaVia:. Use code COMMUNE2026 for 25% off at CocoaVia.com LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 25% off your order at vivobarefoot.com/commune. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.