# GLP-1s Gave Me the Ick: A Personal Metabolic Experiment

Page: https://stenobird.com/podcast/commune-with-jeff-krasno-923764/glp-1s-gave-me-the-ick-a-personal-metabolic-experiment
Text version: https://stenobird.com/podcast/commune-with-jeff-krasno-923764/glp-1s-gave-me-the-ick-a-personal-metabolic-experiment.md
Podcast: [Commune with Jeff Krasno](https://stenobird.com/podcast/commune-with-jeff-krasno-923764)
Published: 2026-07-25T13:05:00+00:00
Episode link: https://traffic.megaphone.fm/COMM6818616966.mp3
Audio file: https://traffic.megaphone.fm/COMM6818616966.mp3
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JSON: https://stenobird.com/v1/public/podcasts/commune-with-jeff-krasno-923764/episodes/glp-1s-gave-me-the-ick-a-personal-metabolic-experiment
Duration seconds: 1118

## Resource

Ten pounds in two weeks. No hunger. No craving for coffee or alcohol. This is Jeff’s personal, week-by-week account of starting tirzepatide (sold as Zepbound), tracked through blood sugar, cholesterol markers, and a noticeable dimming of everyday motivation and joy. What changed in the first two weeks: appetite, weight, and energy Tracking glucose, LDL, ApoB, and other metabolic markers with a CGM and blood panels Why alcohol and coffee stopped feeling rewarding The emerging link between GLP-1s, dopamine, and the brain's reward circuitry The trade-off between appetite control and a sense of vitality or spark This episode is for anyone weighing GLP-1s for themselves, or curious what the drugs are actually like beyond the headlines. This episode was made possible by: CocoaVia:. Use code COMMUNE2026 for 25% off at CocoaVia.com LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at ⁠⁠drinklmnt.com/commune⁠⁠. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 25% off your order at ⁠⁠vivobarefoot.com/commune⁠⁠. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.

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## Transcript

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