Episode
Hepcidin-DMT1 interaction and GPRC5D-targeting bispecific antibody for MM
- Podcast
- Blood Podcast
- Published
- Mar 12, 2026
- Duration seconds
- 932
- Processing state
not_requested- Canonical source
- https://share.transistor.fm/s/f752e487
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Summary
In this week's episode, Blood editor Dr. Laura Michaelis interviews authors Drs. Marion Falabrègue and Ajai Chari on their papers published in volume 146 issue 24 of Blood . The work of Dr. Falabrègue and colleagues in " Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation " indicates that iron absorption from the apical surface of enterocytes can be modulated through manipulation of the hepcidin-DMT1 interaction, opening new avenues for research and therapeutic manipulation. " Talquetamab plus daratumumab in multiple myeloma " features a phase 1b/2 trial of 65 heavily pretreated patients with MM, where Chari et al combined daratumumab and talquetamab, a GPRC5D-targeting bispecific antibody, reporting depletion of CD38-expressing regulatory T cells following daratumumab and impressive efficacy, with an 80% overall (57% complete) response rate and median progression-free survival of 23.3 months. This regimen is now being evaluated in a phase 3 trial.