# Hepcidin-DMT1 interaction and GPRC5D-targeting bispecific antibody for MM

Page: https://stenobird.com/podcast/blood-podcast-664776/hepcidin-dmt1-interaction-and-gprc5d-targeting-bispecific-antibody-for-mm
Text version: https://stenobird.com/podcast/blood-podcast-664776/hepcidin-dmt1-interaction-and-gprc5d-targeting-bispecific-antibody-for-mm.md
Podcast: [Blood Podcast](https://stenobird.com/podcast/blood-podcast-664776)
Published: 2026-03-12T16:00:00+00:00
Episode link: https://share.transistor.fm/s/f752e487
Audio file: https://prfx.byspotify.com/e/media.transistor.fm/f752e487/c3b26e69.mp3
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Duration seconds: 932

## Resource

In this week's episode, Blood editor Dr. Laura Michaelis interviews authors Drs. Marion Falabrègue and Ajai Chari on their papers published in volume 146 issue 24 of Blood . The work of Dr. Falabrègue and colleagues in " Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation " indicates that iron absorption from the apical surface of enterocytes can be modulated through manipulation of the hepcidin-DMT1 interaction, opening new avenues for research and therapeutic manipulation. " Talquetamab plus daratumumab in multiple myeloma " features a phase 1b/2 trial of 65 heavily pretreated patients with MM, where Chari et al combined daratumumab and talquetamab, a GPRC5D-targeting bispecific antibody, reporting depletion of CD38-expressing regulatory T cells following daratumumab and impressive efficacy, with an 80% overall (57% complete) response rate and median progression-free survival of 23.3 months. This regimen is now being evaluated in a phase 3 trial.

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