Episode
CH in children with SCD and Asciminib for CML in the ASC4FIRST trial
- Podcast
- Blood Podcast
- Published
- Mar 26, 2026
- Duration seconds
- 815
- Processing state
not_requested- Canonical source
- https://share.transistor.fm/s/f8bc777b
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Summary
In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Alexander Bick and Jorge Cortes on their latest papers published in Blood . Dr. Cortes, the current EIC of Blood Global Hematology discusses " Asciminib Demonstrates Superior Efficacy and Safety in Newly Diagnosed Chronic Myeloid Leukemia in the ASC4FIRST Trial " wherein the planned secondary analysis showed a further efficacy advantage and a consistently favorable safety profile for asciminib relative to investigator-selected TKIs, especially second-generation TKIs. Dr. Bick discusses " Increased prevalence of clonal hematopoiesis in children with sickle cell disease " where targeted sequencing for CH mutations in 2318 children with SCD and 2957 controls and found that children with SCD have a higher prevalence of CH, and majority of CH cases identified were very small “micro-CH” clones, more work is needed to define the clinical significance of these clones.