# CH in children with SCD and Asciminib for CML in the ASC4FIRST trial

Page: https://stenobird.com/podcast/blood-podcast-664776/ch-in-children-with-scd-and-asciminib-for-cml-in-the-asc4first-trial
Text version: https://stenobird.com/podcast/blood-podcast-664776/ch-in-children-with-scd-and-asciminib-for-cml-in-the-asc4first-trial.md
Podcast: [Blood Podcast](https://stenobird.com/podcast/blood-podcast-664776)
Published: 2026-03-26T16:43:47+00:00
Episode link: https://share.transistor.fm/s/f8bc777b
Audio file: https://prfx.byspotify.com/e/media.transistor.fm/f8bc777b/476751ab.mp3
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JSON: https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/ch-in-children-with-scd-and-asciminib-for-cml-in-the-asc4first-trial
Duration seconds: 815

## Resource

In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Alexander Bick and Jorge Cortes on their latest papers published in Blood . Dr. Cortes, the current EIC of Blood Global Hematology discusses " Asciminib Demonstrates Superior Efficacy and Safety in Newly Diagnosed Chronic Myeloid Leukemia in the ASC4FIRST Trial " wherein the planned secondary analysis showed a further efficacy advantage and a consistently favorable safety profile for asciminib relative to investigator-selected TKIs, especially second-generation TKIs. Dr. Bick discusses " Increased prevalence of clonal hematopoiesis in children with sickle cell disease " where targeted sequencing for CH mutations in 2318 children with SCD and 2957 controls and found that children with SCD have a higher prevalence of CH, and majority of CH cases identified were very small “micro-CH” clones, more work is needed to define the clinical significance of these clones.

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## Transcript

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