Episode
Dr. Tyler Panzner: Hidden Trade-Offs of Longevity Supplements and the Advantage of Topical Delivery
- Published
- Jun 3, 2026
- Duration seconds
- 4170
- Processing state
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- HTTPS://www.younggoose.com
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Summary
Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain. For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it. In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He is a PhD pharmacologist with research in neuropharmacology and breast cancer metastasis, and has worked with over 900 clients, particularly highly sensitive people, to identify their genetic weak points and remove the supplements quietly working against them. If you are stacking longevity supplements, feel wired without explanation, or want to understand why your body responds differently than the marketing promises, this episode is for you. What's Discussed: 03:15 Why supplements are the "Wild West" of holistic health. 08:42 The hidden problem with curcumin, resveratrol, and EGCG for sensitive people. 15:30 The four gas pedals of the brain: adrenaline, histamine, glutamate, and sulfur. 22:18 Stress vs. anxiety and how the brain builds narratives around physiological activation. 29:45 Why your meditation practice may be failing because of a supplement. 37:20 NMN degradation, the NAMPT "toll booth," and topical vs. systemic delivery. 46:08 The future of multi-omics testing and personalized protocols. Find more from Young Goose: Use code PODCAST10 to get 10% off your first purchase, a…