{"podcast":{"title":"Biohacking Beauty: The Anti-Aging Skincare Podcast","slug":"biohacking-beauty-the-anti-aging-skincare-podcast-1375977","podcast_index_feed_id":1375977,"rss_url":"https://feeds.captivate.fm/biohacking-beauty/","website_url":"HTTPS://www.younggoose.com","image_url":"https://artwork.captivate.fm/298ca83b-8d04-48e9-9f13-64ac81e5b188/l62-_tnpsPe0KH5sj9Zklzmu.jpg","author":"Young Goose","episode_count":270,"summary":"Welcome to Biohacking Beauty, the definitive exploration of skin health through the lens of longevity medicine and cellular biology. Hosted by the founders of Young Goose, Amitay Eshel and Anastasia Khodzhaeva, this podcast moves beyond \"single-molecule\" trends to uncover the multi-mechanism protocols required to optimize the body’s largest organ. We bridge the gap between systemic longevity research and topical application. By hosting world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, we translate complex research into actionable strategies for biological recalibration. From the 12 Hallmarks of Aging to the latest in bio-harmonizing lifestyle shifts, Biohacking Beauty provides the molecular tools and insights needed to align your skin’s appearance with your body’s peak biological potential.","last_synced_at":"2026-09-16T16:20:58.251623+00:00","page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977"},"episode":{"title":"Dr. Tyler Panzner: Hidden Trade-Offs of Longevity Supplements and the Advantage of Topical Delivery","slug":"dr-tyler-panzner-hidden-trade-offs-of-longevity-supplements-and-the-advantage-of-topical-delivery","published_at":"2026-06-03T08:00:00+00:00","page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/dr-tyler-panzner-hidden-trade-offs-of-longevity-supplements-and-the-advantage-of-topical-delivery","show_page_url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977","url":"HTTPS://www.younggoose.com","audio_url":"https://episodes.captivate.fm/episode/142ce7bc-2c42-4d44-9e36-816b1f63ffbd.mp3","summary":"Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain. For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it. In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He is a PhD pharmacologist with research in neuropharmacology and breast cancer metastasis, and has worked with over 900 clients, particularly highly sensitive people, to identify their genetic weak points and remove the supplements quietly working against them. If you are stacking longevity supplements, feel wired without explanation, or want to understand why your body responds differently than the marketing promises, this episode is for you. What's Discussed: 03:15 Why supplements are the \"Wild West\" of holistic health. 08:42 The hidden problem with curcumin, resveratrol, and EGCG for sensitive people. 15:30 The four gas pedals of the brain: adrenaline, histamine, glutamate, and sulfur. 22:18 Stress vs. anxiety and how the brain builds narratives around physiological activation. 29:45 Why your meditation practice may be failing because of a supplement. 37:20 NMN degradation, the NAMPT \"toll booth,\" and topical vs. systemic delivery. 46:08 The future of multi-omics testing and personalized protocols. Find more from Young Goose: Use code PODCAST10 to get 10% off your first purchase, a…","meta_description":"Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and s…","key_points":[],"chapters":[],"topics":[],"duration_seconds":4170,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/episodes/dr-tyler-panzner-hidden-trade-offs-of-longevity-supplements-and-the-advantage-of-topical-delivery/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/biohacking-beauty-the-anti-aging-skincare-podcast-1375977/dr-tyler-panzner-hidden-trade-offs-of-longevity-supplements-and-the-advantage-of-topical-delivery.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}