Episode
The Peptides Quietly Accelerating Aging | Dr Valter Longo
- Podcast
- The Proof with Simon Hill
- Published
- May 11, 2026
- Duration seconds
- 6456
- Processing state
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Summary
The peptide and GLP-1 conversation has reached a fever pitch. Growth-hormone-releasing peptides are being marketed as longevity tools, GLP-1s are being treated as a default rather than a last resort, and a wellness aesthetic of higher IGF-1, more muscle, and less fat is being sold as the route to a longer life. In this episode, I sit down with Dr Valter Longo, Professor of Gerontology at USC and Director of the USC Longevity Institute, to look at what the data actually says. Valter developed the Fasting-Mimicking Diet, has led foundational work on the growth hormone, IGF-1, insulin, and TOR axis across yeast, mice, and humans, and runs non-profit longevity foundation clinics in Europe and the US. He calls himself the anti-biohacker and makes the case using the totality of evidence rather than the loudest claim. What we cover: The peptide boom and why every line of evidence cuts the other way The body composition reality of GLP-1s after 3 to 4 years The optimal IGF-1 range and how to land there with food and timing The Fasting-Mimicking Diet across more than 47 clinical trials, including the biological-age reduction studies The Harvard plant-versus-animal protein data, properly read A grounded case against ketogenic patterns for longevity and what to eat instead If this conversation lands, a quick rating or review on Apple Podcasts or Spotify makes a real difference. To follow more of Dr Valter Longo's work, visit his website, find him on Instagram, and explore the work of the Create Cures Foundation, the Valter Longo Foundation, the Longevity Technology Institute, and the European Longevity Institute through his published research and his book The Longevity Diet. Intro (00:00) The Peptide Boom and What Is Actually Being Sold (00:01) GLP-1s: 92 Per Cent Drop-Out and the…