Episode
Nobody Tells You What GLP-1s Do to Your Sex Drive | GLS #213
- Podcast
- The Dr. Gabrielle Lyon Show
- Published
- Jun 25, 2026
- Duration seconds
- 2264
- Processing state
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Summary
The receptor that switches off your appetite on a GLP-1 drug is the same one wired into your reward circuitry, your hormones, and your blood vessels, which means when you turn down hunger, something else may be getting turned down too, and for most people taking these drugs, nobody ever checked. In this solo episode, Dr. Gabrielle Lyon discusses: Why the same drug class can improve sexual function in men with obesity while potentially dampening it in lean or postmenopausal women — and why the deciding factor isn't the drug, it's the body How rapid weight loss raises SHBG, the protein that soaks up free testosterone, so a "normal" total testosterone result can hide a real deficit your bloodwork won't flag Why women make up 60–70% of GLP-1 prescriptions yet the entire evidence base for female sexual function is two case reports, with zero validated questionnaires in any pivotal trial The three-tier action plan for anyone on or about to start a GLP-1 — baseline your sexual function first, get free testosterone tested, and protect muscle with protein and resistance training Whether you're on a GLP-1 drug or considering one, you'll walk away knowing exactly what to measure before you start and what to watch for after — so a change in your sexual health gets caught as the vital sign it is, instead of being quietly dismissed. Thank you to our sponsors: Cozy Earth - Go to https://bit.ly/44qcXtu for up to 20% off! Lucy - Get 20% off your next order with code DRLYON at https://bit.ly/3QEpYMX or find yours in store at https://bit.ly/3SGAEv3 . Kettle & Fire - Head to https://bit.ly/4oJokGu and use code DRLYON for 25% off sitewide. That is K-E-T-T-L-E and Fire dot com slash DRLYON, code DRLYON for 25% off. Also available at select Sprouts, Whole Foods, and Kroger locations nati…