Episode
9. 15-Minute Consult: New Research in Vestibulodynia with Dr. Jill Krapf
- Published
- Jun 9, 2026
- Duration seconds
- 1044
- Processing state
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- https://zencastr.com/z/RXQx2WJT
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Summary
If you experience severe, sharp burning at the vaginal opening, you know how frustrating the journey to a clear diagnosis can be. In this episode, world-renowned pelvic pain expert Dr. Jill Krapf [https://www.vulvodynia.com/about] joins Dr. Rachel Pope to share a massive milestone in neuroinflammatory vulvar pain research: a gold-standard, 3-month clinical trial testing a brand-new topical Ketotifen cream. Ketotifen is a mast cell stabilizer historically used for allergies, but it has never before been formulated into a topical cream for pelvic pain. This breakthrough treatment directly targets the "neuroinflammatory zone," calming hyper-reactive mast cells and hypersensitive nerve endings. Key Takeaways: * The Clinical Protocol: To track improvement, the trial uses two precise baseline tests: a specialized Q-Tip pressure monitor at the vestibule (requiring a 5/10 pain score to qualify) and a gentle dilator insertion test. Patient comfort is the absolute priority; tests stop immediately if pain thresholds are hit. * A Pure Passion Project: Funding for localized vulvar pain is notoriously low. Backed by a small grant from the National Vulvodynia Association (NVA) [https://www.nva.org/], this trial is a true labor of love by Dr. Krapf, Dr. Andrew Goldstein, and Dr. Chailee Moss to provide a non-surgical alternative for patients. * How to Get Screened: Active trials are currently recruiting. Reach out directly to the site closest to you: The Centers for Vulvovaginal Disorders Research Details & Locations: * Duration: Approximately 3 months (only 4 short in-person study visits). * Locations: Tampa (FL), Washington D.C., and New York City. Tampa, (FL): * Lichen Scelorus research: [email protected] Vulvodynia Research: * Washington, DC- [email protected] * New Yor…