Episode
What You Need to Know About the #1 Leading Cause of Death in Women
- Podcast
- Menopause Mastery
- Published
- Apr 1, 2026
- Duration seconds
- 4738
- Processing state
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Summary
The Menopause Mastery Show | Understanding Women's Cardiac Health In Menopause | Episode 272 with John Osborne, MD, PhD, FACC, FNLA 🌱 Welcome to The Menopause Mastery Show! In this episode, Dr. Betty Murray welcomes cardiologist Dr. John Osborne to discuss menopause as a major cardiovascular transition and how women are often misassessed using a male-centered model. They discuss women's higher rates of missed or atypical heart attack symptoms (fatigue, shortness of breath, nausea) and conditions more common in women such as microvascular disease, Takotsubo ("broken heart") cardiomyopathy, and SCAD. Osborne criticizes stress tests and the frequent, unnecessary caths, arguing that prevention should start with imaging—at least a calcium score at ~40, and ideally cardiac CT with AI to detect and quantify soft and calcified plaque, track progression, and guide treatment. They cover menopause-related lipid shifts, low HRT use and recent FDA label changes, and key labs including Lp(a) (genetic; estrogen lowers it; Horizon trial with pelacarsen) and ApoB targets for plaque reversal. 🩺 Discover the untold truths about menopause and heart health in this important installment of The Menopause Mastery Show! Join Dr. Betty and Dr. Osborne as they dive into how women's cardiovascular health is more than you think. To connect with Dr. Osborne: https://clearcardio.com/ You Tube Channel: @ClearCardio 00:00 Menopause Heart Risk 00:38 Why Women Get Missed 03:47 Heart Attack Symptoms 08:28 Microvascular Disease 12:59 Stress Heart Syndromes 16:15 Estrogen and Vessels 19:41 Lipoprotein A Explained 25:29 ApoB Better Marker 29:37 Why Imaging Matters 36:17 Stress Tests Limitations 40:19 Calcium Score Basics 41:31 Calcium Score Basics 42:10 Soft Plaque Blind Spot 43:55 Cardiac CT Full Picture…