Episode
Liver Lineup: Bridging Innovation and Practice in Liver Transplant and HCC Care
- Podcast
- HCPLive Podcasts
- Published
- Feb 4, 2026
- Duration seconds
- 1842
- Processing state
not_requested- Canonical source
- https://audioboom.com/posts/8856842
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Summary
In this episode of Liver Lineup: Updates and Unfiltered Insights, hosts Kimberly Brown, MD, and Nancy Reau, MD, break down new research on liver transplantation, hepatocellular carcinoma (HCC), and the ongoing evolution of surveillance strategies in chronic liver disease. Drawing on their extensive experience as transplant hepatologists, Brown and Reau place new data into practical context, highlighting where evidence may meaningfully inform practice and where unanswered questions remain. Key episode timestamps: 0:00:00 – Introduction 0:00:19 – Frailty & Transplant Evaluation 0:02:54 – How Centers Use Frailty Measures 0:04:37 – Practicalities of the Six‑Minute Walk 0:06:10 – MELD 3.0 and Sex/Size Disparities 0:08:42 – Exception Points & Size Constraints 0:10:05 – Need for a Dynamic MELD System 0:10:19 – Immunotherapy as Bridge/Downstaging for HCC 0:13:34 – Real‑World Use of IO Around Transplant 0:15:22 – Managing Rejection Risk 0:19:03 – MASLD Population & Surveillance Gaps 0:20:21 – Adherence to HCC Surveillance 0:22:42 – Practical Barriers: AFP, Ultrasound, Radiology Reports 0:24:02 – Shift Toward Blood-Based Surveillance 0:26:01 – How AFP-L3 and DCP Are Used in Practice 0:27:39 – Rising AFP, Imaging Strategy & Broader Trend to Blood Tests 0:28:27 – Guidelines vs Real-World Practice 0:29:37 – Closing Thoughts on Guidelines & Early Detection