Episode
Reprogramming the cell from aged to healthy with siRNA - Dr. Janine & Rob (Junevity)
- Podcast
- Free Radicals
- Published
- Dec 9, 2025
- Duration seconds
- 4319
- Processing state
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Summary
Dr. Janine Sengstack and Rob Cahill, founders of the startup Junevity, are on a mission to extend lifespan and healthspan by combining AI and large scale omics data with genetic medicines known as “siRNAs”. Their cellular reset platform promises to create medicines that can reset each of your organs back to a healthy and youthful state.This year, Junevity successfully restored "18-year-old metabolism" in animal models allowing mice on a high-fat diet to lose fat while retaining muscle. This candidate therapy may become the first known drug to rejuvenate metabolism. Since our recording, Junevity doubled their seed round funding up to $20M to advance this work into human clinical trials, which means we might see their first rejuvenating medicine in the clinic as soon as the second half of next year.