Episode
EP Edge® Journal Watch Issue 30: VISION AF, Pulsed Field Ablation Safety, PACE-HF and Conduction System Pacing | July 2026
- Published
- Jul 27, 2026
- Duration seconds
- 1436
- Processing state
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- https://share.transistor.fm/s/abfaa9bf
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Summary
In EP Edge® Journal Watch Issue 30, July 2026 , we explore the next phase of cardiac electrophysiology, from pulsed field ablation durability and physiologic pacing to neuromodulation, sleep, fitness, and lifetime arrhythmia risk. We begin with the first-in-human VISION AF study , which evaluates an endoscope-enabled pulsed field ablation balloon that allows direct visualization of the electrode-tissue interface. Chronic invasive remapping provides a close look at pulmonary vein isolation durability and raises an important question: could seeing tissue contact become the next major advance in PFA workflow? Two additional studies examine practical PFA safety signals. One evaluates hemolysis-associated acute kidney injury, pulse count, chronic kidney disease, extensive left atrial ablation, and whether protocol-based hydration can reduce renal risk. Another quantifies acute blood pressure drops during circular-array PFA and identifies the first pulmonary vein treatment as the period of greatest hemodynamic vulnerability. The pacing and ventricular arrhythmia section includes: The randomized PACE-HF trial , comparing left bundle branch area pacing with conventional right ventricular pacing A preclinical comparison of left bundle branch area antitachycardia pacing and right ventricular ATP Pulsed ultrahigh-frequency spinal cord stimulation as a potential neuromodulation strategy after myocardial infarction We then move beyond the EP laboratory to examine: Insomnia and incident atrial fibrillation The lifetime cardiovascular tradeoff between high cardiorespiratory fitness and AF risk Whether the balance of moderate and vigorous physical activity influences cardiovascular and overall mortality Each paper is examined through its rationale, methodology, statistical meaning, li…