Episode
EP Edge Journal Watch Issue 22: PFA Safety, Lesion Durability, LAAO, Subcutaneous-ICD Testing & AF Ablation Success
- Podcast
- EP Edge Journal Watch
- Published
- May 18, 2026
- Duration seconds
- 2017
- Processing state
not_requested- Canonical source
- https://share.transistor.fm/s/6f69b53c
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Summary
In this episode of EP Edge® Journal Watch , Dr. Sharma reviews Issue 22, May 2026, focused on the next phase of electrophysiology: pulsed field ablation safety, lesion durability, long-term AF recurrence, one-stop AF procedures, device simplification, PAC suppression, and the evolving definition of ablation success. This issue begins with the Ferro EHRA 2026 real-world comparison of pulsed field ablation versus radiofrequency ablation for atrial fibrillation, highlighting why PFA safety should be interpreted by endpoint, workflow, platform, and lesion strategy rather than as a single global claim. The episode then examines NAVIGATE-PF Phase 2 , a systematic remapping study of a second-generation, mapping-integrated pentaspline PFA catheter, and what early lesion durability tells us about the future of anatomically accountable PFA. Dr. Sharma also discusses long-term recurrence after pentaspline PFA, including predictors of AF recurrence and what redo procedures reveal about pulmonary vein reconnection among patients with recurrent arrhythmia. Additional studies include concomitant PFA plus left atrial appendage occlusion , exploring whether a one-stop AF strategy may improve procedural efficiency and reduce peridevice leak; PRAETORIAN-DFT , evaluating whether routine defibrillation testing can be omitted after S-ICD implantation when implant position is favorable; and a CT-based risk score for predicting difficult leadless pacemaker implantation . The episode also covers a provocative phase 2 randomized trial of memantine for premature atrial contractions , introducing NMDA receptor antagonism as a potential nontraditional pathway for atrial ectopy suppression. Finally, this issue closes with a critical look at how we define success after AF ablation. Is the traditiona…