Episode
The Secret Brain Defenders That Protect Against Dementia & Alzheimer's with Dr David Perlmutter
- Published
- Aug 18, 2026
- Duration seconds
- 4145
- Processing state
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Summary
In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation. Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear. You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future. In This Episode: 00:00 Amyloid Myth Busted 00:15 Show Intro and Guest 04:18 Book Inspiration Microglia 06:02 Symptom Care vs Root Cause 09:51 Microglia M1 vs M2 11:15 Gut Brain Inflammation Link 15:01 Metabolism Mirrors Microglia 17:57 Infections Vaccines and Triggers 19:31 CTE Diabetes and Feedforward 25:20 New Tools and Beta Amyloid Drugs 30:37 Cochrane Verdict Drugs Fail 33:28 Lifestyle Trial Reverses Decline 38:23 Microglia Lifestyle Levers 39:07 Exercise Myokines Brain Boost 42:20 Alzheimers Risk Epigenetics 45:12 Imaging Microglia TSPO 46:24 Fasting Ketones Brain Fuel 49:45 MCT Oil Memory Care 51:16 POINTER Lifestyle Trial 55:57 Fiber Polyphenols Foods 58:34 Supplements DHA Vitamin D 01:02:23 Key Labs Glucose Tau 01:06:19 Prevention Mission Wrap 01:07:43 Final Thanks Outro Enjoy a clean, protein-packed snack with PaleoValley's Grass-Fed Beef Sticks. Made w…