Episode
Top Psychiatric Expert Warns: "I Couldn't Get Off My Own Antidepressant. Here’s What Every Patient Needs to Know!” with Dr. Mark Horowitz
- Podcast
- Dhru Purohit Show
- Published
- Jun 17, 2026
- Duration seconds
- 5399
- Processing state
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Summary
This episode is brought to you by Rythm Health, Momentous, Bon Charge, and Branch Basics. Millions of people take antidepressants to manage anxiety and depression, yet many questions remain about their long-term effectiveness and what happens when people try to stop taking them. As concerns grow about withdrawal symptoms and the challenges of coming off these medications, understanding both their benefits and limitations has never been more important. Today on The Dhru Purohit Show, Dhru sits down with Dr. Mark Horowitz to explore the widespread use of antidepressants, why so many people struggle to come off them, and how withdrawal symptoms are often misunderstood. Dr. Horowitz shares his own difficult experience tapering off antidepressants and how it inspired him to research and develop safer, evidence-based approaches for reducing these medications. He also examines the research on how antidepressants were originally approved, highlighting key limitations in some studies and how those flaws may have shaped our understanding of their benefits and risks. Along the way, he explains what happens in the brain during the tapering process and the best and worst practices for supporting individuals dealing with anxiety, depression, and antidepressant discontinuation. Dr. Mark Horowitz is a Clinical Research Fellow in Psychiatry with the NHS in London, Visiting Lecturer at King’s College London, and lead author of the Maudsley Deprescribing Guidelines, the first authoritative handbook on safely stopping antidepressants and other psychiatric medications. His research has helped shape UK national guidance on tapering psychiatric drugs, and he has published in leading journals including The Lancet Psychiatry and JAMA Psychiatry. Drawing from both his clinical expertise and per…