Episode

The Diels-Alder and Other Pericyclic Reactions: Crash Course Organic Chemistry #42

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CrashCourse
Published
Sep 18, 2026
Duration seconds
1035
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not_requested
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Summary

Going out in the sun can work wonders for your mood, but unfortunately too much UV exposure can do serious damage to your DNA. This damage occurs through a type of organic reaction called a pericyclic reaction. In this episode of Crash Course Organic Chemistry, we’ll explore pericyclic reactions to see how the sun can both give us life, and hurt us, and also look at other important pericyclic reactions, such as the Diels-Alder reaction.Episode Sources:https://cen.acs.org/articles/95/i15/Remembering-organic-chemistry-legend-Robert-Burns-Woodward.htmlhttps://www.nobelprize.org/prizes/chemistry/1950/alder/biographical/ https://www.nobelprize.org/prizes/chemistry/1981/summary/https://www.nobelprize.org/prizes/chemistry/1981/fukui/facts/ https://www.uni-kiel.de/grosse-forscher/index.php?nid=diels⟨=eOhashi, M., Jamieson, C.S., Cai, Y. et al. An enzymatic Alder-ene reaction. Nature 586, 64–69 (2020). https://doi.org/10.1038/s41586-020-2743-5Further Reading on Pericyclic Reactions and the Woodward-Hoffman Rules: https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Supplemental_Modules_(Organic_Chemistry)/Reactions/Pericyclic_ReactionsFleming, I. (1977). Frontier orbitals and organic chemical reactions. Wiley.Series Sources:Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publish…