{"podcast":{"title":"The Science of Age-less Living","slug":"the-science-of-age-less-living-7235688","podcast_index_feed_id":7235688,"rss_url":"https://media.rss.com/the-science-of-age-less-living/feed.xml","website_url":"https://rss.com/podcasts/the-science-of-age-less-living/","image_url":"https://media.rss.com/the-science-of-age-less-living/20251203_051216_dcfbba3c86faaedb3846ad2813128728.png","author":"Dr. Ethan Hausman-Marquis","episode_count":37,"summary":"Welcome to The Science of Age-Less Living ! Dr. Ethan Hausman-Marquis—logevity researcher, biohacker and founder of The Catalyst Clinic—shares his journey into the fields of aesthetics, regenerative medicine, and longevity science, and offers a look at what the future of aging may hold. From his early studies at UCLA to advanced work in genomics and molecular biology at L’École Normale Supérieure in Paris and a PhD at the Karolinska Institute in Stockholm, Dr. Ethan’s path has been guided by one goal: helping people live longer, healthier, and more vibrant lives. He is the author of Exploring the World of Peptides: From Basics to Breakthroughs and Peptide-Based Cancer Therapies: A New Frontier in Precision Medicine , and has contributed to several peer-reviewed publications on cutting-edge medical research. In this episode, Dr. Ethan reflects on his transition from academic research to clinical innovation at The Catalyst Clinic—with locations in London, New York, Amsterdam, and soon Zürich—and sets the stage for what’s to come in future episodes. Each week, The Science of Age-Less Living explores the molecular and cell biology of longevity—the evolving landscape of regenerative me…","last_synced_at":"2026-06-25T22:18:53.982257+00:00","page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688"},"episode":{"title":"Tesamorelin: The Age-less Pulse of Growth Hormone | Age-Less Top 20 Peptides","slug":"tesamorelin-the-age-less-pulse-of-growth-hormone-age-less-top-20-peptides","published_at":"2026-06-03T20:03:33+00:00","page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688/tesamorelin-the-age-less-pulse-of-growth-hormone-age-less-top-20-peptides","show_page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688","url":"https://rss.com/podcasts/the-science-of-age-less-living/2883374","audio_url":"https://content.rss.com/episodes/319089/2883374/the-science-of-age-less-living/2026_06_03_20_03_27_fa02d2d8-e00d-4b13-b575-9e6b7f8e39f7.mp3","summary":"In the mid-1990s, antiretroviral therapy was transforming HIV from a death sentence into a chronic condition — and creating an unexpected syndrome in its wake. Patients on the new combinations were developing visceral fat accumulation, peripheral fat loss, dyslipidaemia, and a measurably blunted growth hormone rhythm. A small Canadian biotech in Montréal saw the lever. Native GHRH had a half-life of seven minutes, cleaved almost instantly by an enzyme called DPP-IV. Their structural innovation — adding a single trans-3-hexenoic acid group to the N-terminus — blocked the cleavage site, extended the half-life to twenty-six minutes, and made an entire pharmacology clinically viable. That compound is Tesamorelin, and in 2010 it became one of the very few synthetic peptides ever to clear the full FDA approval pathway. In this episode, Dr. Ethan walks through the molecule properly. The forty-four amino acid sequence, the structural modification that makes it work, and the mechanism that distinguishes it from every other growth hormone strategy: Tesamorelin doesn't introduce GH, it activates the body's own pituitary to release GH in its natural pulsatile pattern, preserving somatostatin feedback and the physiological rhythm that exogenous rhGH abolishes. The episode follows the cascade from GHRH receptor binding through cAMP and PKA activation to pulsatile GH release, hepatic IGF-1 production, and the anabolic and lipolytic effects downstream. Then the human evidence — and this is where Tesamorelin sits in a category of its own. Two pivotal Phase III trials, fifteen years of post-marketing data, and a defined safety profile in HIV-associated lipodystrophy. Emerging Phase II data in MASLD showing meaningful reductions in hepatic fat. Exploratory work in cognitive function, sar…","meta_description":"In the mid-1990s, antiretroviral therapy was transforming HIV from a death sentence into a chronic condition — and creating an unexpected syndrome in its…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1514,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-science-of-age-less-living-7235688/episodes/tesamorelin-the-age-less-pulse-of-growth-hormone-age-less-top-20-peptides/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688/tesamorelin-the-age-less-pulse-of-growth-hormone-age-less-top-20-peptides.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}