{"podcast":{"title":"The Science of Age-less Living","slug":"the-science-of-age-less-living-7235688","podcast_index_feed_id":7235688,"rss_url":"https://media.rss.com/the-science-of-age-less-living/feed.xml","website_url":"https://rss.com/podcasts/the-science-of-age-less-living/","image_url":"https://media.rss.com/the-science-of-age-less-living/20251203_051216_dcfbba3c86faaedb3846ad2813128728.png","author":"Dr. Ethan Hausman-Marquis","episode_count":37,"summary":"Welcome to The Science of Age-Less Living ! Dr. Ethan Hausman-Marquis—logevity researcher, biohacker and founder of The Catalyst Clinic—shares his journey into the fields of aesthetics, regenerative medicine, and longevity science, and offers a look at what the future of aging may hold. From his early studies at UCLA to advanced work in genomics and molecular biology at L’École Normale Supérieure in Paris and a PhD at the Karolinska Institute in Stockholm, Dr. Ethan’s path has been guided by one goal: helping people live longer, healthier, and more vibrant lives. He is the author of Exploring the World of Peptides: From Basics to Breakthroughs and Peptide-Based Cancer Therapies: A New Frontier in Precision Medicine , and has contributed to several peer-reviewed publications on cutting-edge medical research. In this episode, Dr. Ethan reflects on his transition from academic research to clinical innovation at The Catalyst Clinic—with locations in London, New York, Amsterdam, and soon Zürich—and sets the stage for what’s to come in future episodes. Each week, The Science of Age-Less Living explores the molecular and cell biology of longevity—the evolving landscape of regenerative me…","last_synced_at":"2026-06-25T22:18:53.982257+00:00","page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688"},"episode":{"title":"Klotho: The Longevity Hormone You've Never Heard Of  | Age-Less Top 20 Peptides","slug":"klotho-the-longevity-hormone-you-ve-never-heard-of-age-less-top-20-peptides","published_at":"2026-05-27T09:40:32+00:00","page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688/klotho-the-longevity-hormone-you-ve-never-heard-of-age-less-top-20-peptides","show_page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688","url":"https://rss.com/podcasts/the-science-of-age-less-living/2862282","audio_url":"https://content.rss.com/episodes/319089/2862282/the-science-of-age-less-living/2026_05_27_09_40_26_2bdca86a-fc2a-4030-8155-e7abe7696f8f.mp3","summary":"Klotho was discovered in 1997 when a disrupted gene caused mice to develop every hallmark of premature ageing within weeks — osteoporosis, arteriosclerosis, muscle wasting, cognitive decline — and die at a fraction of their expected lifespan. The inverse experiment extended lifespan by twenty to thirty percent. The protein was named after Clotho, the Greek Fate who spins the thread of life. It remains one of the most studied proteins in longevity biology nearly three decades later. In this episode, Dr. Ethan Hausman-Marquis examines Klotho from the ground up: the critical distinction between transmembrane α-Klotho and its circulating shed form sKlotho; how the FGF23 co-receptor mechanism explains the accelerated ageing phenotype of Klotho deficiency; what five separate longevity-associated pathways — including IGF-1/PI3K suppression, Wnt/β-catenin inhibition, Nrf2 antioxidant activation, and TGF-beta fibrosis suppression — suggest about why this protein matters so broadly; and why circulating Klotho levels decline by approximately 40 percent between the ages of 40 and 80. The human evidence is examined honestly: what the large prospective cohort studies actually show, what the KL-VS genetic variant data adds to the causal argument, what the 2014 Cell Reports cognitive findings mean for neurodegeneration research, and why the interventional human data — despite the extraordinary preclinical picture — is essentially non-existent. The evidence base, the interventional frontier, the exercise and vitamin D data, and the honest assessment of where exogenous Klotho research actually stands in 2026 — all of it, examined without hype. If you're researching Klotho supplementation, Klotho and ageing, Klotho and cognitive decline, or the science behind longevity peptides and anti-…","meta_description":"Klotho was discovered in 1997 when a disrupted gene caused mice to develop every hallmark of premature ageing within weeks — osteoporosis, arteriosclerosi…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1302,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-science-of-age-less-living-7235688/episodes/klotho-the-longevity-hormone-you-ve-never-heard-of-age-less-top-20-peptides/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688/klotho-the-longevity-hormone-you-ve-never-heard-of-age-less-top-20-peptides.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}