{"podcast":{"title":"The Science of Age-less Living","slug":"the-science-of-age-less-living-7235688","podcast_index_feed_id":7235688,"rss_url":"https://media.rss.com/the-science-of-age-less-living/feed.xml","website_url":"https://rss.com/podcasts/the-science-of-age-less-living/","image_url":"https://media.rss.com/the-science-of-age-less-living/20251203_051216_dcfbba3c86faaedb3846ad2813128728.png","author":"Dr. Ethan Hausman-Marquis","episode_count":37,"summary":"Welcome to The Science of Age-Less Living ! Dr. Ethan Hausman-Marquis—logevity researcher, biohacker and founder of The Catalyst Clinic—shares his journey into the fields of aesthetics, regenerative medicine, and longevity science, and offers a look at what the future of aging may hold. From his early studies at UCLA to advanced work in genomics and molecular biology at L’École Normale Supérieure in Paris and a PhD at the Karolinska Institute in Stockholm, Dr. Ethan’s path has been guided by one goal: helping people live longer, healthier, and more vibrant lives. He is the author of Exploring the World of Peptides: From Basics to Breakthroughs and Peptide-Based Cancer Therapies: A New Frontier in Precision Medicine , and has contributed to several peer-reviewed publications on cutting-edge medical research. In this episode, Dr. Ethan reflects on his transition from academic research to clinical innovation at The Catalyst Clinic—with locations in London, New York, Amsterdam, and soon Zürich—and sets the stage for what’s to come in future episodes. Each week, The Science of Age-Less Living explores the molecular and cell biology of longevity—the evolving landscape of regenerative me…","last_synced_at":"2026-06-25T22:18:53.982257+00:00","page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688"},"episode":{"title":"Genetic Pathways to Longevity: Harnessing Polygenic Risk Scores for Personalized Age-less Interventions","slug":"genetic-pathways-to-longevity-harnessing-polygenic-risk-scores-for-personalized-age-less-interventions","published_at":"2025-09-06T19:09:17+00:00","page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688/genetic-pathways-to-longevity-harnessing-polygenic-risk-scores-for-personalized-age-less-interventions","show_page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688","url":"https://rss.com/podcasts/the-science-of-age-less-living/2202700","audio_url":"https://content.rss.com/episodes/319089/2202700/the-science-of-age-less-living/2025_09_06_19_08_27_b13f3cc9-60c5-4879-b4d6-9d5081e1c26a.mp3","summary":"Dive into polygenic risk scores (PRS) and discover how your genetic blueprint can inform personalized longevity strategies. Dr. Ethan Hausman-Marquis breaks down genome sequencing, five major genetic pathways to aging (DNA repair, metabolism, inflammation, mitochondria, neurodegeneration), and real-world clinical applications from The Catalyst Clinic. Learn how PRS can shift prevention from one-size-fits-all to truly individualized interventions—while understanding limits like population bias and probabilistic risk. Perfect for longevity science fans curious about precision medicine, NAD+, peptides, and building cognitive and mitochondrial resilience. If this episode helped you, please like and share with someone interested in age-less living. #PolygenicRiskScore #Longevity #PrecisionMedicine #AntiAging #Genomics OUTLINE: 00:00:00 Title and Introduction 00:02:35 Genes Aren't Destiny 00:06:19 What Is a Polygenic Risk Score? 00:10:28 Two Patients Example 00:13:17 Five Major Pathways 00:20:58 Limitations and Caveats 00:25:30 Clinical Application 00:27:56 Emotional Impact 00:29:58 Closing Reflection","meta_description":"Dive into polygenic risk scores (PRS) and discover how your genetic blueprint can inform personalized longevity strategies. Dr. Ethan Hausman-Marquis brea…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1851,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-science-of-age-less-living-7235688/episodes/genetic-pathways-to-longevity-harnessing-polygenic-risk-scores-for-personalized-age-less-interventions/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688/genetic-pathways-to-longevity-harnessing-polygenic-risk-scores-for-personalized-age-less-interventions.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}