{"podcast":{"title":"The Science of Age-less Living","slug":"the-science-of-age-less-living-7235688","podcast_index_feed_id":7235688,"rss_url":"https://media.rss.com/the-science-of-age-less-living/feed.xml","website_url":"https://rss.com/podcasts/the-science-of-age-less-living/","image_url":"https://media.rss.com/the-science-of-age-less-living/20251203_051216_dcfbba3c86faaedb3846ad2813128728.png","author":"Dr. Ethan Hausman-Marquis","episode_count":37,"summary":"Welcome to The Science of Age-Less Living ! Dr. Ethan Hausman-Marquis—logevity researcher, biohacker and founder of The Catalyst Clinic—shares his journey into the fields of aesthetics, regenerative medicine, and longevity science, and offers a look at what the future of aging may hold. From his early studies at UCLA to advanced work in genomics and molecular biology at L’École Normale Supérieure in Paris and a PhD at the Karolinska Institute in Stockholm, Dr. Ethan’s path has been guided by one goal: helping people live longer, healthier, and more vibrant lives. He is the author of Exploring the World of Peptides: From Basics to Breakthroughs and Peptide-Based Cancer Therapies: A New Frontier in Precision Medicine , and has contributed to several peer-reviewed publications on cutting-edge medical research. In this episode, Dr. Ethan reflects on his transition from academic research to clinical innovation at The Catalyst Clinic—with locations in London, New York, Amsterdam, and soon Zürich—and sets the stage for what’s to come in future episodes. Each week, The Science of Age-Less Living explores the molecular and cell biology of longevity—the evolving landscape of regenerative me…","last_synced_at":"2026-06-25T22:18:53.982257+00:00","page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688"},"episode":{"title":"Age-Less Cognition: The Real Science of SEMAX | Age-Less Top 20 Peptides","slug":"age-less-cognition-the-real-science-of-semax-age-less-top-20-peptides","published_at":"2026-06-25T10:29:00+00:00","page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688/age-less-cognition-the-real-science-of-semax-age-less-top-20-peptides","show_page_url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688","url":"https://rss.com/podcasts/the-science-of-age-less-living/2942749","audio_url":"https://content.rss.com/episodes/319089/2942749/the-science-of-age-less-living/2026_06_25_10_28_49_b597c64d-e02e-41dd-b278-338baca096c3.mp3","summary":"SEMAX is one of the most discussed cognitive compounds in the longevity and nootropic world — and arguably one of the most poorly understood. In this episode, Dr. Ethan does what this series always does: follows the science wherever it leads, without the hype and without the dismissiveness. The story of SEMAX starts not in a supplement company's marketing department, but in a Soviet government research institute in the 1980s, where neuropeptide scientists were asking a genuinely interesting question: could fragments of ACTH — the pituitary hormone best known for driving cortisol production — exert direct effects on the brain entirely independent of the adrenal axis? The answer was yes. And SEMAX was the engineered result: a stable, intranasally bioavailable heptapeptide designed to deliver those neuropeptide effects to the central nervous system. The mechanistic story is one of the more coherent in this series. SEMAX upregulates BDNF — brain-derived neurotrophic factor — in hippocampal and prefrontal circuits, the very regions most implicated in age-related cognitive decline. It modulates serotonin availability. It attenuates neuroinflammatory cascades. Each of those mechanisms has a plausible link to cognitive ageing, and together they form a rational basis for the compound's proposed effects. The evidence picture is more complicated. SEMAX has genuine peer-reviewed data — animal studies, Russian clinical trials in stroke and cerebrovascular disease, a 40-year research history. It is a licensed pharmaceutical in Russia, not a grey-market research chemical. But the clinical data has real structural limitations, and for the application most listeners are actually interested in — sharper cognition in a healthy ageing adult — the human randomised controlled trial evidence…","meta_description":"SEMAX is one of the most discussed cognitive compounds in the longevity and nootropic world — and arguably one of the most poorly understood. In this epis…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1900,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-science-of-age-less-living-7235688/episodes/age-less-cognition-the-real-science-of-semax-age-less-top-20-peptides/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-science-of-age-less-living-7235688/age-less-cognition-the-real-science-of-semax-age-less-top-20-peptides.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}