{"podcast":{"title":"The Resus Room","slug":"the-resus-room-743091","podcast_index_feed_id":743091,"rss_url":"https://theresusroom.libsyn.com/rss","website_url":"http://www.theresusroom.co.uk","image_url":"https://static.libsyn.com/p/assets/2/b/4/c/2b4c20e7a20344bba04421dee9605cbd/TE_RESUS_ROOM.png","author":"Simon Laing","episode_count":286,"summary":"Emergency Medicine podcasts based on evidence based medicine focussed on practice in and around the resus room.","last_synced_at":"2026-08-02T06:17:15.179925+00:00","page_url":"https://stenobird.com/podcast/the-resus-room-743091"},"episode":{"title":"Sickle Cell Disease; Roadside to Resus","slug":"sickle-cell-disease-roadside-to-resus","published_at":"2025-09-15T00:01:00+00:00","page_url":"https://stenobird.com/podcast/the-resus-room-743091/sickle-cell-disease-roadside-to-resus","show_page_url":"https://stenobird.com/podcast/the-resus-room-743091","url":"https://theresusroom.libsyn.com/sickle-cell-disease-roadside-to-resus","audio_url":"https://traffic.libsyn.com/secure/theresusroom/Sickle_Cell_R2R_for_iTunes.mp3?dest-id=367790","summary":"a focus on its acute presentations and the care we can deliver to improve outcomes for our patients. Sickle cell disease (SCD) is a lifelong inherited blood disorder that affects over 15,000 people in the UK, and millions worldwide. It's caused by the production of abnormal haemoglobin molecules, which distort red blood cells into a crescent, or \"sickle,\" shape. These rigid cells can block small blood vessels, leading to painful vaso-occlusive crises and organ damage. While the condition has long been most prevalent in parts of Africa, the Middle East, the Mediterranean and India, today it's a global health issue, and one we encounter regularly in UK emergency care. Tragically, failings in care have too often led to avoidable harm. The 2021 parliamentary report \"No One's Listening\" laid bare some of these cases, highlighting missed opportunities, poor awareness, and systemic issues that cost lives, such as the death of Evan Nathan Smith. So why are we revisiting this now? In 2024, RCEM published new Best Practice Guidelines on managing sickle cell disease in the ED. These provide clear, evidence-based standards for recognition, triage, analgesia, infection control, and safe discharge. In this episode, we take you through the key elements; Pathophysiology – how a genetic mutation drives sickling, vaso-occlusion and inflammation. Clinical presentations – from painful crises and acute chest syndrome, to stroke, anaemia, infection, priapism and pregnancy-related complications. Recognition and triage – why timely pain control within 30 minutes is a must, and how to spot red flags. Investigations and treatment – including the role of reticulocytes, the importance of knowing a patient's baseline haemoglobin, and principles of analgesia, transfusion, oxygen, and supportive car…","meta_description":"a focus on its acute presentations and the care we can deliver to improve outcomes for our patients. Sickle cell disease (SCD) is a lifelong inherited blo…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3081,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-resus-room-743091/episodes/sickle-cell-disease-roadside-to-resus/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-resus-room-743091/sickle-cell-disease-roadside-to-resus.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}