{"podcast":{"title":"The ReProgram","slug":"the-reprogram-7585130","podcast_index_feed_id":7585130,"rss_url":"https://anchor.fm/s/10b3944a8/podcast/rss","website_url":"https://murphylaboratory.com/","image_url":"https://d3t3ozftmdmh3i.cloudfront.net/staging/podcast_uploaded_nologo/44732698/44732698-1771971066998-927516406dd09.jpg","author":"Dr. George Murphy","episode_count":21,"summary":"The ReProgram is dedicated to exploring how we can extend the healthy human lifespan through science and self-understanding. Hosted by Dr. George Murphy, each episode dives into the rapidly evolving fields of aging biology, longevity, regenerative medicine, and geroscience. From cellular rejuvenation and advanced therapeutics to lifestyle strategies that build resilience against disease, we examine what the science actually shows—and what it doesn’t. No hype. No myths. Just rigorous, evidence-based conversations about how we can reprogram our biology to live longer and healthier lives.","last_synced_at":"2026-07-07T06:17:35.175675+00:00","page_url":"https://stenobird.com/podcast/the-reprogram-7585130"},"episode":{"title":"Measuring and Modifying Biological Age: What the Science Actually Shows","slug":"measuring-and-modifying-biological-age-what-the-science-actually-shows","published_at":"2026-05-04T16:00:00+00:00","page_url":"https://stenobird.com/podcast/the-reprogram-7585130/measuring-and-modifying-biological-age-what-the-science-actually-shows","show_page_url":"https://stenobird.com/podcast/the-reprogram-7585130","url":"https://podcasters.spotify.com/pod/show/thereprogrampodcast/episodes/Measuring-and-Modifying-Biological-Age-What-the-Science-Actually-Shows-e3ip4f9","audio_url":"https://anchor.fm/s/10b3944a8/podcast/play/119361449/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2026-4-2%2F423301398-44100-2-d81e600d3eb28.mp3","summary":"ReProgram Episode 13 🧠 Episode Overview What does it actually mean to measure your biological age—and can it be changed? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Jesse Poganik, a leading scientist in the field of biological aging clocks and biomarkers of aging. Together, they unpack the science behind biological age—how it’s measured, what it reflects, and whether it represents a causal driver of aging or simply a readout of deeper biological processes. This conversation goes beyond the hype. It explores the emerging tools used to quantify aging, the limitations of current approaches, and what it will take to translate these measurements into meaningful clinical interventions. From organ transplantation to immune system signaling, Dr. Poganik shares how real-world biological systems are helping decode the mechanisms that shape how we age. 🔑 Keywords biological age, epigenetic clocks, aging biomarkers, DNA methylation, longevity science, healthspan, resilience, systems biology, immune aging, biomarkers of aging, translational medicine, aging mechanisms, clinical biomarkers, longevity interventions 🔬 What You’ll Learn • What “biological age” actually measures—and what it doesn’t • How epigenetic clocks are built and why they’ve gained traction • The difference between correlation and causation in aging biomarkers • Why systemic signals (like blood and immune factors) may regulate aging • How organ transplantation provides a natural experiment in aging biology • The biggest challenges in bringing biological age testing into the clinic • What standardization efforts (like the Biomarkers of Aging Consortium) aim to solve • Whether modifying biological age is currently possible—and what’s coming next 🎙️ The ReProgram Perspective Biological age i…","meta_description":"ReProgram Episode 13 🧠 Episode Overview What does it actually mean to measure your biological age—and can it be changed? In this episode of The ReProgram,…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2658,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-reprogram-7585130/episodes/measuring-and-modifying-biological-age-what-the-science-actually-shows/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-reprogram-7585130/measuring-and-modifying-biological-age-what-the-science-actually-shows.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}