{"podcast":{"title":"The Readout Loud","slug":"the-readout-loud-1134305","podcast_index_feed_id":1134305,"rss_url":"https://feeds.megaphone.fm/thereadoutloud","website_url":"https://soundcloud.com/readout-loud","image_url":"https://megaphone.imgix.net/podcasts/2700b5c2-6d26-11ee-87eb-1f9099431c15/image/517bb4949d560305bb39448edbb32d7a.jpg?ixlib=rails-4.3.1&max-w=3000&max-h=3000&fit=crop&auto=format,compress","author":"STAT","episode_count":414,"summary":"STAT’s weekly biotech podcast, breaking down the latest news, digging deep into industry goings-on, and giving you a preview of the week to come.","last_synced_at":"2026-07-17T08:20:19.054206+00:00","page_url":"https://stenobird.com/podcast/the-readout-loud-1134305"},"episode":{"title":"391: Breaching the IBD efficacy ceiling, and sham surgeries","slug":"391-breaching-the-ibd-efficacy-ceiling-and-sham-surgeries","published_at":"2026-03-05T17:35:00+00:00","page_url":"https://stenobird.com/podcast/the-readout-loud-1134305/391-breaching-the-ibd-efficacy-ceiling-and-sham-surgeries","show_page_url":"https://stenobird.com/podcast/the-readout-loud-1134305","url":"https://traffic.megaphone.fm/TTSAA9607085727.mp3?updated=1772735911","audio_url":"https://traffic.megaphone.fm/TTSAA9607085727.mp3?updated=1772735911","summary":"Will drugmakers finally be able to breach the efficacy ceiling in inflammatory bowel disease? And is the Food and Drug Administration being flexible enough with rare disease treatments? Spyre Therapeutics CEO Cameron Turtle joins the podcast to discuss his company's experimental IBD medications, and whether the drug industry is scraping the barrel in the search for better treatments. We also discuss the latest news in the life sciences, including the ongoing debate between the FDA and UniQure over its Huntington's disease therapy, as well as Moderna's mammoth patent settlement.","meta_description":"Will drugmakers finally be able to breach the efficacy ceiling in inflammatory bowel disease? And is the Food and Drug Administration being flexible enoug…","key_points":[],"chapters":[],"topics":[],"duration_seconds":1829,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-readout-loud-1134305/episodes/391-breaching-the-ibd-efficacy-ceiling-and-sham-surgeries/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-readout-loud-1134305/391-breaching-the-ibd-efficacy-ceiling-and-sham-surgeries.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}