{"podcast":{"title":"The Natural Alternative - with Madonna Guy","slug":"the-natural-alternative-with-madonna-guy-5290149","podcast_index_feed_id":5290149,"rss_url":"https://audioboom.com/channels/5073029.rss","website_url":"https://audioboom.com/channels/5073029","image_url":"https://audioboom.com/i/39043559/s=1400x1400/el=1/rt=fill.jpg","author":"The Natural Alternative - with Madonna Guy ND","episode_count":405,"summary":"\"I aim to have honest conversations with anyone who can add interest, knowledge, love and healing on the planet. If they have knowledge that can help us heal - body, mind and soul - I'm happy to have a chat with them and share with you!\" As my skills improve (technology wise) I'll be sharing information in an editorial / information sharing format as well. Madonna has been studying healing modalities for 3 decades and has been a kinesiology trainer for over 15 years. As a naturopath and kinesiologist, energetic healer and nutritionist, herbalist and homeopath, radio guest for a dozen years - there is a massive amount of knowledge that she has to draw from. Find me on YouTube: New Leaf Health Team Facebook: Madonna Guy at New Leaf Natural Therapies Facebook: The Brain Centre @ New Leaf Natural Therapies Twitter: @NewLeafTweets Bitchute: The Natural Alternative with Madonna Guy Join my mailing list at www.NewLeafNaturalTherapies.com or email me at healthteam@newleafnaturaltherapies.com.au","last_synced_at":"2026-06-12T12:19:31.294827+00:00","page_url":"https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149"},"episode":{"title":"355: Oxalates, Histamines & GLP1 GLP2 & GIP Resistance:  How Plant Toxins Disrupt Signalling & Metabolism","slug":"355-oxalates-histamines-glp1-glp2-gip-resistance-how-plant-toxins-disrupt-signalling-metabolism","published_at":"2026-05-14T05:50:14+00:00","page_url":"https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149/355-oxalates-histamines-glp1-glp2-gip-resistance-how-plant-toxins-disrupt-signalling-metabolism","show_page_url":"https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149","url":"https://audioboom.com/posts/8903381","audio_url":"https://audioboom.com/posts/8903381.mp3?modified=1778737863&sid=5073029&source=rss","summary":"Madonna’s recap highlights a powerful but often overlooked concept: plant‑derived irritants like oxalates and histamines can inflame the gut lining, activate mast cells, and injure L cells—the very cells responsible for producing GLP‑1, GLP‑2, and GIP. When these cells are stressed or damaged, incretin release becomes blunted, nutrient sensing becomes unreliable, and the gut becomes more permeable. This creates a state of functional incretin resistance , where the body technically produces incretins but cannot use them effectively. The downstream effects—poor satiety, unstable blood sugar, cravings, weight dysregulation, and hormonal flares—show up most strongly in people with oxalate dumping, MCAS, SIBO, endometriosis, and chronic gut inflammation. She also explained how histamine excess and oxalate‑triggered inflammation disrupt vagal tone and gut‑brain communication, reduce SCFA production, increase histamine‑forming bacteria, and damage brush‑border receptors. All of this suppresses GLP‑1 and GLP‑2 secretion while increasing sympathetic stress signalling. This is why many clients feel “resistant” to their own incretins until the gut environment is repaired. Madonna emphasized that tri‑GLP supplements are helping people restore satiety, stabilize blood sugar, and reduce inflammation by supporting the very pathways that oxalates and histamines disrupt. Hashtag Bundle #IncretinResistance #GLP1 #GLP2 #GIP #Oxalates #Histamines #MCAS #GutHealth #LeakyGut #Endometriosis #MetabolicHealth #TriGLP #LCells #Microbiome #VagalTone #FunctionalMedicine #Inflammation #BloodSugarBalance #SatietyScience #GutBrainAxis","meta_description":"Madonna’s recap highlights a powerful but often overlooked concept: plant‑derived irritants like oxalates and histamines can inflame the gut lining, activ…","key_points":[],"chapters":[],"topics":[],"duration_seconds":413,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-natural-alternative-with-madonna-guy-5290149/episodes/355-oxalates-histamines-glp1-glp2-gip-resistance-how-plant-toxins-disrupt-signalling-metabolism/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-natural-alternative-with-madonna-guy-5290149/355-oxalates-histamines-glp1-glp2-gip-resistance-how-plant-toxins-disrupt-signalling-metabolism.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}