{"podcast":{"title":"The Itch: Allergies, Asthma, Eczema & Immunology","slug":"the-itch-allergies-asthma-eczema-immunology-1162107","podcast_index_feed_id":1162107,"rss_url":"https://theitchpodcast.podbean.com/feed.xml","website_url":"https://www.itchpodcast.com/","image_url":"https://pbcdn1.podbean.com/imglogo/image-logo/3726381/The_Itch_Podcast_IRL_SQ_thumbnail_1600x8oy7d.png","author":"The Itch: Allergies, Asthma & Immunology","episode_count":163,"summary":"Itching to know more about environmental and food allergies, asthma or immunology? Leave Dr Google at home and tune in as Kortney (a real life food allergy girl) and Dr Gupta (allergist/immunologist) discuss all things allergies, asthma and immunology. They want to bring you the facts in an easily digestible manner. From deep dives to interviews they will cover the science and the lifestyle aspects of life with allergies, asthma or immunology.","last_synced_at":"2026-06-13T04:20:02.703958+00:00","page_url":"https://stenobird.com/podcast/the-itch-allergies-asthma-eczema-immunology-1162107"},"episode":{"title":"#147 -The REMIX Trial: Remibrutinib for Chronic Hives","slug":"147-the-remix-trial-remibrutinib-for-chronic-hives","published_at":"2026-03-06T12:35:57+00:00","page_url":"https://stenobird.com/podcast/the-itch-allergies-asthma-eczema-immunology-1162107/147-the-remix-trial-remibrutinib-for-chronic-hives","show_page_url":"https://stenobird.com/podcast/the-itch-allergies-asthma-eczema-immunology-1162107","url":"https://theitchpodcast.podbean.com/e/147-the-remix-trial-remibrutinib-for-chronic-hives/","audio_url":"https://mcdn.podbean.com/mf/web/88udjfrzhjgdiutc/Ep_147_REMIX_Trialb4qky.mp3","summary":"If you have chronic hives and antihistamines aren't helping, there's a new treatment option to know about. In this episode of The Itch Review, we spotlight \"Remibrutinib in Chronic Spontaneous Urticaria\" published in The New England Journal of Medicine, March 2025. This article looks at the REMIX trials, which tested whether remibrutinib, a BTK inhibitor, can help adults whose chronic spontaneous urticaria (CSU) is not controlled by antihistamines alone. Remibrutinib works differently from antihistamines. Instead of blocking histamine after it's released, it stops mast cells from releasing those itch-causing chemicals in the first place. The FDA approved remibrutinib in September 2025. What we cover in our episode about the REMIX trial: Understanding CSU: Chronic spontaneous urticaria causes itchy hives and swelling for more than 6 weeks with no clear trigger, and antihistamines don't work for everyone. How remibrutinib works: This BTK inhibitor stops mast cells from releasing chemicals like histamine, rather than blocking histamine after it's already released. Why do two identical trials: Running the same study twice (REMIX-1 and REMIX-2) with different patients helps prove the results are real, not a fluke. Key results: About half of patients reached well-controlled disease, and about 1 in 3 became completely clear of hives and itch. Safety and side effects: Petechiae (tiny dots of bleeding under the skin) were the main thing to watch for, but most cases were mild and went away on their own. DOWNLOAD THE INFOGRAPHIC More resources about chronic hives Chronic Spontaneous Urticaria - Allergy & Asthma Network Chronic Urticaria Toolkit What are hives? All episodes on urticaria *********** The Itch Review, hosted by Dr. Gupta, Kortney, and Dr. Blaiss, explores allergy…","meta_description":"If you have chronic hives and antihistamines aren't helping, there's a new treatment option to know about. In this episode of The Itch Review, we spotligh…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2456,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-itch-allergies-asthma-eczema-immunology-1162107/episodes/147-the-remix-trial-remibrutinib-for-chronic-hives/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-itch-allergies-asthma-eczema-immunology-1162107/147-the-remix-trial-remibrutinib-for-chronic-hives.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}