{"podcast":{"title":"The Human Upgrade: Biohacking for Longevity & Performance","slug":"the-human-upgrade-biohacking-for-longevity-performance-1031629","podcast_index_feed_id":1031629,"rss_url":"https://rss.art19.com/human-upgrade","website_url":"https://daveasprey.com/category/podcasts/","image_url":"https://content.production.cdn.art19.com/images/8a/08/50/8c/8a08508c-e0b0-4761-8eeb-e26d8dcc9a11/c8b0e53403b0f567938e72d32ba01ad021e82e8517b3c2e7a9d8367fcb5253a0472522241e7b60d9298bddc2eba33b5a9f5ac4df0023690ae76b17d3dad50d33.jpeg","author":"Dave Asprey","episode_count":1558,"summary":"For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.","last_synced_at":"2026-07-18T04:21:16.572334+00:00","page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629"},"episode":{"title":"Flouride and IQ, Sardinemaxxing, At Home Cancer Cure, Hair Loss Fixes, and more...  : 1451","slug":"flouride-and-iq-sardinemaxxing-at-home-cancer-cure-hair-loss-fixes-and-more-1451","published_at":"2026-04-17T08:30:00+00:00","page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/flouride-and-iq-sardinemaxxing-at-home-cancer-cure-hair-loss-fixes-and-more-1451","show_page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629","url":"https://dts.podtrac.com/redirect.mp3/mgln.ai/e/p394/rss.art19.com/episodes/6495f605-560a-459a-b267-4a9d6963db8b.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0","audio_url":"https://dts.podtrac.com/redirect.mp3/mgln.ai/e/p394/rss.art19.com/episodes/6495f605-560a-459a-b267-4a9d6963db8b.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0","summary":"This week's stories:  ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer***  A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administered seven doses directly into her tumor outside formal clinical infrastructure. Four years cancer-free. Dave breaks down the mechanistic basis for oncolytic virotherapy—why cancer cells can't mount antiviral defenses that healthy tissue can—and the regulatory tension between patient autonomy and FDA gatekeeping on experimental immunotherapies. This is either a triumph of DIY biohacking or a cautionary tale about biosafety; either way, oncolytic virotherapy is accelerating toward mainstream clinical use and forcing a reckoning about access to cutting-edge cancer immunology.  Sources:  - https://www.dana-farber.org/newsroom/news-releases/2026/virus-based-therapy-boosts-anti-cancer-immune-responses-to-brain-cancer   - https://www.eurekalert.org/news-releases/1116087   - https://acgtfoundation.org/news/oncolytic-virus-therapy-for-cancer/     ***Spermidine is the Missing Link Between Fasting and Longevity***  A Nature Cell Biology study across yeast, flies, mice, and humans reveals that fasting triggers longevity exclusively through spermidine—blocking spermidine synthesis ablates every lifespan-extending benefit, cardioprotection, and anti-inflammatory outcome, even with identical caloric restriction. Dave explains why your intermittent fasting protocol is metabolically inert without spermidine, the specific foods highest in bioavailable spermidine (wheat germ, aged cheddar, shii…","meta_description":"This week's stories: ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer***&nbs…","key_points":[],"chapters":[],"topics":[],"duration_seconds":664,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-human-upgrade-biohacking-for-longevity-performance-1031629/episodes/flouride-and-iq-sardinemaxxing-at-home-cancer-cure-hair-loss-fixes-and-more-1451/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/flouride-and-iq-sardinemaxxing-at-home-cancer-cure-hair-loss-fixes-and-more-1451.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}