{"podcast":{"title":"The Human Upgrade: Biohacking for Longevity & Performance","slug":"the-human-upgrade-biohacking-for-longevity-performance-1031629","podcast_index_feed_id":1031629,"rss_url":"https://rss.art19.com/human-upgrade","website_url":"https://daveasprey.com/category/podcasts/","image_url":"https://content.production.cdn.art19.com/images/8a/08/50/8c/8a08508c-e0b0-4761-8eeb-e26d8dcc9a11/c8b0e53403b0f567938e72d32ba01ad021e82e8517b3c2e7a9d8367fcb5253a0472522241e7b60d9298bddc2eba33b5a9f5ac4df0023690ae76b17d3dad50d33.jpeg","author":"Dave Asprey","episode_count":1558,"summary":"For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.","last_synced_at":"2026-07-18T04:21:16.572334+00:00","page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629"},"episode":{"title":"CDC Director Jim O'Neill on Fixing America's Broken Food Policy  : 1449","slug":"cdc-director-jim-o-neill-on-fixing-america-s-broken-food-policy-1449","published_at":"2026-04-14T08:30:00+00:00","page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/cdc-director-jim-o-neill-on-fixing-america-s-broken-food-policy-1449","show_page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629","url":"https://dts.podtrac.com/redirect.mp3/mgln.ai/e/p394/rss.art19.com/episodes/bdc56d27-00e9-43fe-9e36-73e809c6ec5d.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0","audio_url":"https://dts.podtrac.com/redirect.mp3/mgln.ai/e/p394/rss.art19.com/episodes/bdc56d27-00e9-43fe-9e36-73e809c6ec5d.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0","summary":"The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like.    Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Jim O'Neill served as Deputy Secretary of Health and Human Services and Acting Director of the CDC before being nominated to lead the National Science Foundation in March 2026. Before entering government, he was CEO of SENS Research Foundation, where he led cutting-edge regenerative medicine research targeting mitochondrial mutations, senescent cells, and neocortex rejuvenation. He is a 30-year veteran of health care reform and a genuine longevity insider.  Dave and Jim cover the complete rewrite of federal dietary guidelines, the government's new randomized controlled trials on saturated fats, and why grains are no longer the core of a \"balanced diet.\" They dig into a 144 million dollar ARPA H program to establish causal aging biomarkers that will unlock real anti-aging drug development and accelerate the kind of longevity research the SENS Foundation pioneered. Jim explains why current aging clocks and DNA methylation markers are not enough, and what comes next for functional medicine, sleep optimization, and metabolism research. They also break down the CDC's return to its infectious disease core, the future of AI in health care, wearable data for disease surveillance, organ bioprinting, GLP-1s, supplements like vitamin D, peptides, and the right to self-experiment.  You will learn:  Why the new federal di…","meta_description":"The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2195,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-human-upgrade-biohacking-for-longevity-performance-1031629/episodes/cdc-director-jim-o-neill-on-fixing-america-s-broken-food-policy-1449/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/cdc-director-jim-o-neill-on-fixing-america-s-broken-food-policy-1449.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}