{"podcast":{"title":"The Human Upgrade: Biohacking for Longevity & Performance","slug":"the-human-upgrade-biohacking-for-longevity-performance-1031629","podcast_index_feed_id":1031629,"rss_url":"https://rss.art19.com/human-upgrade","website_url":"https://daveasprey.com/category/podcasts/","image_url":"https://content.production.cdn.art19.com/images/8a/08/50/8c/8a08508c-e0b0-4761-8eeb-e26d8dcc9a11/c8b0e53403b0f567938e72d32ba01ad021e82e8517b3c2e7a9d8367fcb5253a0472522241e7b60d9298bddc2eba33b5a9f5ac4df0023690ae76b17d3dad50d33.jpeg","author":"Dave Asprey","episode_count":1558,"summary":"For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.","last_synced_at":"2026-07-18T04:21:16.572334+00:00","page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629"},"episode":{"title":"BONUS: The Anti-Aging Molecule Backed by Nobel Prize Research : 1492","slug":"bonus-the-anti-aging-molecule-backed-by-nobel-prize-research-1492","published_at":"2026-06-28T08:30:00+00:00","page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/bonus-the-anti-aging-molecule-backed-by-nobel-prize-research-1492","show_page_url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629","url":"https://dts.podtrac.com/redirect.mp3/mgln.ai/e/p394/rss.art19.com/episodes/084de429-e5b3-48e1-84de-d2c97281e07d.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0","audio_url":"https://dts.podtrac.com/redirect.mp3/mgln.ai/e/p394/rss.art19.com/episodes/084de429-e5b3-48e1-84de-d2c97281e07d.mp3?rss_browser=BAhJIg90cmFuc2NyaWJyBjoGRVQ%3D--952c5701c84ad333c69d5faa668f8177091704f0","summary":"You already know something has changed - the energy crashes, the slow recovery, the brain fog that wasn't there ten years ago. Most people assume that's just aging. But it’s NOT. Nobel Prize-winning research has identified a single molecule that controls how fast your body breaks down, and more importantly, exactly why yours is being destroyed faster than it's being rebuilt. The fix isn't complicated, but the order you do it in matters. In this video, Dave breaks down what this molecule is, why your body is actively working against it, and the exact protocol (diet, fasting, exercise, and supplementation) to restore it before the gap gets any wider. Thank you to our sponsors! Gatlan | Book your free consultation at  www.gatlan.com/DAVE Viome | Check it out at  viome.com  and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. iRestore | Reverse hair loss at  www.irestore.com/DAVE  and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 0:00 – The Longevity Switch 0:47 – Why Mitochondria Matter 2:28 – What Mitophagy Is 2:46 – How Mitophagy Works 4:18 – What Shuts It Off 8:54 – The Damage Compounds 9:22 – How to Turn It Back On 10:31 – Signal 1: Fasting 11:48 – Signal 2: Exercise (REHIT) 12:30 – Signal 3: Cold Exposure 13:22 – Signal 4: NAD+ 14:29 – Signal 5: Urolithin A and Spermidine Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Cof…","meta_description":"You already know something has changed - the energy crashes, the slow recovery, the brain fog that wasn't there ten years ago. Most people assume that's j…","key_points":[],"chapters":[],"topics":[],"duration_seconds":745,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-human-upgrade-biohacking-for-longevity-performance-1031629/episodes/bonus-the-anti-aging-molecule-backed-by-nobel-prize-research-1492/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-human-upgrade-biohacking-for-longevity-performance-1031629/bonus-the-anti-aging-molecule-backed-by-nobel-prize-research-1492.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}