{"podcast":{"title":"Giants Shoulder","slug":"the-giants-shoulder-6943930","podcast_index_feed_id":6943930,"rss_url":"https://anchor.fm/s/f592b1d4/podcast/rss","website_url":"https://podcasters.spotify.com/pod/show/evanmcgloughlin","image_url":"https://d3t3ozftmdmh3i.cloudfront.net/staging/podcast_uploaded_nologo/41100317/41100317-1740226956129-96396ebc63bd9.jpg","author":"Evan McGloughlin","episode_count":140,"summary":"A Neuroscience podcast. Each week I talk with experts on a range of topics from consciousness and neuroplasticity to evolution and everything in between. I have a particular interest in consciousness and understanding our inner subjective conscious experience. Evan has a Neuroscience degree from Trinity College Dublin and is the co-founder of 2 (failed) edtech startups. He is a professional tennis coach and Triathlete enthusiast.","last_synced_at":"2026-07-03T04:19:34.566536+00:00","page_url":"https://stenobird.com/podcast/the-giants-shoulder-6943930"},"episode":{"title":"#116 Meet The World’s Greatest Psychedelic Receptor Scientist","slug":"116-meet-the-world-s-greatest-psychedelic-receptor-scientist","published_at":"2026-04-30T15:42:56+00:00","page_url":"https://stenobird.com/podcast/the-giants-shoulder-6943930/116-meet-the-world-s-greatest-psychedelic-receptor-scientist","show_page_url":"https://stenobird.com/podcast/the-giants-shoulder-6943930","url":"https://podcasters.spotify.com/pod/show/evanmcgloughlin/episodes/116-Meet-The-Worlds-Greatest-Psychedelic-Receptor-Scientist-e3imv5o","audio_url":"https://traffic.megaphone.fm/APO2351867765.mp3","summary":"Bryan L. Roth is a drug receptor scientist who solved the crystal structure of LSD inside a serotonin receptor and took $26.9 million from DARPA to build a non-hallucinogenic psychedelic — a compound that hits the same receptor as psilocybin, produces antidepressant effects in mice, and doesn't cause a trip. Expect to learn how his mother's schizophrenia launched a 40-year career in pharmacology, why Salvia divinorum has zero serotonin activity and works entirely through the kappa opioid receptor, why serotonin and opioid receptors converge in the claustrum, why DARPA funded non-hallucinogenic alternatives for soldiers, how his lab screens a trillion compounds that don't physically exist, why only 100 of 26,000 protein targets have ever been drugged, and much more… Timestamps: 00:00 Bryan L. Roth — The Man Who Builds Non-Hallucinogenic Psychedelics 02:41 Falling Into Receptor Science by Accident 04:58 When Only 5 People on Earth Studied Psychedelic Receptors 06:07 Why "Psychedelic" Was Banned From Research Grants 07:28 The 2016 Papers That Changed Everything 08:26 The Scientist Friend Who Got "Cured" by Psilocybin 10:41 The Vietnam Vet With a Gun in His Mouth — Ibogaine's Power 12:50 What Is Ibogaine and Why Can It Kill You? 18:06 Why the Kappa Opioid System Breaks Reality 19:07 The Hidden History of Psychotomimetic Opioids 22:16 Why Opioid Researchers Deny Kappa Causes Hallucinations 23:18 The Claustrum: Where Serotonin and Opioid Receptors Meet 24:14 Multiple Entry Points Into Reality-Altering Brain Systems 28:35 Why Psychedelic Experiences Feel So Meaningful 29:58 DMT: "More Real Than Reality" — And Nobody Knows Why 31:28 Salvia: Becoming Plaid on a Wall 33:48 Trump's $50M Psychedelic Order Won't Buy One Clinical Trial 35:33 No Other Ps…","meta_description":"Bryan L. Roth is a drug receptor scientist who solved the crystal structure of LSD inside a serotonin receptor and took $26.9 million from DARPA to build…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3749,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-giants-shoulder-6943930/episodes/116-meet-the-world-s-greatest-psychedelic-receptor-scientist/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-giants-shoulder-6943930/116-meet-the-world-s-greatest-psychedelic-receptor-scientist.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}