{"podcast":{"title":"The Academic Minute","slug":"the-academic-minute-1102038","podcast_index_feed_id":1102038,"rss_url":"https://api.substack.com/feed/podcast/7972926.rss","website_url":"https://www.academicminute.org/podcast","image_url":"https://substackcdn.com/feed/podcast/7972926/3de65ac4cfe10a333128ea1e717f3fde.jpg","author":"Academic Minute","episode_count":1000,"summary":"Astronomy to Zoology","last_synced_at":"2026-07-30T14:17:21.893800+00:00","page_url":"https://stenobird.com/podcast/the-academic-minute-1102038"},"episode":{"title":"John Yates, Scripps Research Institute - Detecting Alzheimer’s Disease Through Changes in Protein Shape","slug":"john-yates-scripps-research-institute-detecting-alzheimer-s-disease-through-changes-in-protein-shape","published_at":"2026-06-12T04:01:00+00:00","page_url":"https://stenobird.com/podcast/the-academic-minute-1102038/john-yates-scripps-research-institute-detecting-alzheimer-s-disease-through-changes-in-protein-shape","show_page_url":"https://stenobird.com/podcast/the-academic-minute-1102038","url":"https://www.academicminute.org/p/john-yates-scripps-research-institute","audio_url":"https://api.substack.com/feed/podcast/200787156/78dfd13d151e84bf5964d47a18a2ec92.mp3","summary":"What can protein shape tell us about Alzheimer’s disease? John Yates , John Lytton Young Professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute , discusses this question. Faculty Bio: John R. Yates III is the John Lytton Young Professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute. He received a B.A in Zoology and an M.S. in Chemistry from the University of Maine at Orono. He obtained his Ph.D. in Chemistry at the University of Virginia in the laboratory of Donald F. Hunt with a dissertation entitled Protein Sequencing by Tandem Mass Spectrometry. He performed postdoctoral research in the laboratory of Leroy E. Hood at California Institute of Technology. At the University of Washington, he obtained the rank of Associate Professor with tenure before moving to The Scripps Research Institute in LaJolla, CA. His research interests include development of integrated methods for tandem mass spectrometry analysis of protein mixtures, bioinformatics using mass spectrometry data, and biological studies involving proteomics. He is the lead inventor of the SEQUEST software for correlating tandem mass spectrometry data to sequences in the database and developer of the shotgun proteomics technique for the analysis of protein mixtures. His laboratory has developed the use of proteomic techniques to analyze protein complexes, posttranslational modifications, organelles and quantitative analysis of protein expression for the discovery of new biology. He has received numerous awards such as the American Society for Mass Spectrometry (ASMS) research award, the Pehr Edman Award in Protein Chemistry, the ASMS Biemann Medal, the HUPO Distinguished Achievement Award in Proteo…","meta_description":"What can protein shape tell us about Alzheimer’s disease? John Yates , John Lytton Young Professor in the Department of Integrative Structural and Computa…","key_points":[],"chapters":[],"topics":[],"duration_seconds":150,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-academic-minute-1102038/episodes/john-yates-scripps-research-institute-detecting-alzheimer-s-disease-through-changes-in-protein-shape/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-academic-minute-1102038/john-yates-scripps-research-institute-detecting-alzheimer-s-disease-through-changes-in-protein-shape.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}