{"podcast":{"title":"The a16z Show","slug":"the-a16z-show-436525","podcast_index_feed_id":436525,"rss_url":"https://feeds.simplecast.com/JGE3yC0V","website_url":"https://a16z.simplecast.com","image_url":"https://image.simplecastcdn.com/images/0d97354a-306b-45f5-bf26-a8d81eef47ec/ed2664df-9371-438e-8baf-dd2ee0fdde87/3000x3000/thea16zshow-podcastcoverart-3000x3000.jpg?aid=rss_feed","author":"a16z","episode_count":1000,"summary":"The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!","last_synced_at":"2026-09-19T16:19:21.546571+00:00","page_url":"https://stenobird.com/podcast/the-a16z-show-436525"},"episode":{"title":"Inside Moderna’s Personalized Cancer Vaccine","slug":"inside-moderna-s-personalized-cancer-vaccine","published_at":"2026-09-02T10:00:00+00:00","page_url":"https://stenobird.com/podcast/the-a16z-show-436525/inside-moderna-s-personalized-cancer-vaccine","show_page_url":"https://stenobird.com/podcast/the-a16z-show-436525","url":"https://a16z.simplecast.com/episodes/inside-modernas-personalized-cancer-vaccine-214RAv4s","audio_url":"https://mgln.ai/e/1344/afp-848985-injected.calisto.simplecastaudio.com/3f86df7b-51c6-4101-88a2-550dba782de8/episodes/457cc002-6623-42f4-8cc7-1bc2f129144b/audio/128/default.mp3?aid=rss_feed&awCollectionId=3f86df7b-51c6-4101-88a2-550dba782de8&awEpisodeId=457cc002-6623-42f4-8cc7-1bc2f129144b&feed=JGE3yC0V","summary":"a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results from Moderna and Merck’s individualized treatment for melanoma, after more than a decade of work on personalized cancer vaccines. Stéphane explains how the treatment works by sequencing an individual patient’s tumor and healthy cells, identifying the mutations most relevant to their cancer, and encoding up to 34 of them into an mRNA designed specifically for that patient. Rather than simply unleashing the immune system, the goal is to teach it exactly what to recognize and attack. They also unpack the engineering challenge of manufacturing a different medicine for every patient, how Moderna has brought the process down to roughly 42 days from biopsy to treatment, and what it would take to manufacture personalized medicines at scale. Finally, Stéphane looks beyond melanoma to lung, kidney, bladder, pancreatic, and gastric cancers, as well as Moderna’s longer-term work applying mRNA to rare genetic and autoimmune diseases.","meta_description":"a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results fro…","key_points":[],"chapters":[],"topics":[],"duration_seconds":2410,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/the-a16z-show-436525/episodes/inside-moderna-s-personalized-cancer-vaccine/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/the-a16z-show-436525/inside-moderna-s-personalized-cancer-vaccine.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}