{"podcast":{"title":"Proof of Practice Podcast","slug":"proof-of-practice-podcast-7864181","podcast_index_feed_id":7864181,"rss_url":"https://api.substack.com/feed/podcast/8580784.rss","website_url":"https://proofpractice.substack.com/podcast","image_url":"https://substackcdn.com/feed/podcast/8580784/f1aaae9107d2fca3a629b902a9b55efd.jpg","author":"To cut through the noise in health and wellness — with honest, research-backed conversations that inspire real people to live longer, stronger, and more fully. No shame, no shortcuts, no wellness theater.","episode_count":8,"summary":"Honest, research-backed conversations that inspire real people to live longer, stronger, and more fully.","last_synced_at":"2026-07-21T00:18:17.665747+00:00","page_url":"https://stenobird.com/podcast/proof-of-practice-podcast-7864181"},"episode":{"title":"Why Women Are Twice as Likely to Get Alzheimer's and What To Do About It | Sandy Gleysteen","slug":"why-women-are-twice-as-likely-to-get-alzheimer-s-and-what-to-do-about-it-sandy-gleysteen","published_at":"2026-05-25T11:00:00+00:00","page_url":"https://stenobird.com/podcast/proof-of-practice-podcast-7864181/why-women-are-twice-as-likely-to-get-alzheimer-s-and-what-to-do-about-it-sandy-gleysteen","show_page_url":"https://stenobird.com/podcast/proof-of-practice-podcast-7864181","url":"https://proofpractice.substack.com/p/why-women-are-twice-as-likely-to","audio_url":"https://api.substack.com/feed/podcast/198685712/5d8dc724a0091b3fcc23fe7b7e7a40f7.mp3","summary":"Sandy Gleysteen, award-winning journalist turned Alzheimer’s advocate and Chief Communications Officer at the Women’s Alzheimer’s Movement (WAM), joins us to unpack why women bear a disproportionate share of Alzheimer’s risk and what can actually be done about it. The conversation covers the critical role of estrogen as a neuroprotector, the window of opportunity around perimenopause and HRT, and the surprising finding that up to 50% of Alzheimer’s cases may be preventable through lifestyle. WHAT WE EXPLORE * Why two-thirds of Alzheimer’s cases are women, and the estrogen connection * Perimenopause as a critical window for brain protection and HRT timing * Up to 50% of Alzheimer’s cases may be preventable with lifestyle changes * Exercise and nutrition as first-line defenses against cognitive decline * How poor sleep allows amyloid plaques to build up in the brain * Why loneliness is as damaging to brain health as smoking two packs a day * The APOE4 gene test: should you get tested, and what to do with results * Creatine for women: brain and body benefits that outpace the research on men * Statins, cholesterol, and a critical open question no one is answering yet * Practical caregiving strategies when someone you love has dementia ABOUT DR SANDY GLEYSTEEN: Sandy Gleysteen spent decades as an Emmy Award-winning television producer at NBC and CBS, partnering with Maria Shriver on some of the most significant women’s journalism of a generation. After witnessing multiple family members navigate memory loss, she earned a Master’s in Gerontology from USC at age 67 and pivoted her career entirely to brain health advocacy. She now serves as Chief Communications Officer at the Women’s Alzheimer’s Movement, co-founded by Maria Shriver, and plays a central role in expanding WAM’s…","meta_description":"Sandy Gleysteen, award-winning journalist turned Alzheimer’s advocate and Chief Communications Officer at the Women’s Alzheimer’s Movement (WAM), joins us…","key_points":[],"chapters":[],"topics":[],"duration_seconds":3152,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/proof-of-practice-podcast-7864181/episodes/why-women-are-twice-as-likely-to-get-alzheimer-s-and-what-to-do-about-it-sandy-gleysteen/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/proof-of-practice-podcast-7864181/why-women-are-twice-as-likely-to-get-alzheimer-s-and-what-to-do-about-it-sandy-gleysteen.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}