{"podcast":{"title":"Owl Posting","slug":"owl-posting-6974455","podcast_index_feed_id":6974455,"rss_url":"https://api.substack.com/feed/podcast/2520497/s/139003.rss","website_url":"https://www.owlposting.com/s/podcast","image_url":"https://substackcdn.com/feed/podcast/2520497/s/139003/5c1267a7053a23eae4b2e6f61eab88e7.jpg","author":"Abhishaike Mahajan","episode_count":11,"summary":"Some audio-based content over biology-ML. Some of these are conversions of existing posts that lend itself well to audio.","last_synced_at":"2026-07-06T10:19:44.481952+00:00","page_url":"https://stenobird.com/podcast/owl-posting-6974455"},"episode":{"title":"What could Alphafold 4 look like? (Sergey Ovchinnikov, Ep #3)","slug":"what-could-alphafold-4-look-like-sergey-ovchinnikov-ep-3","published_at":"2025-04-25T16:24:37+00:00","page_url":"https://stenobird.com/podcast/owl-posting-6974455/what-could-alphafold-4-look-like-sergey-ovchinnikov-ep-3","show_page_url":"https://stenobird.com/podcast/owl-posting-6974455","url":"https://www.owlposting.com/p/what-could-alphafold-4-look-like","audio_url":"https://api.substack.com/feed/podcast/161619288/4836304ff122cbac996130c0adfc2031.mp3","summary":"X: https://x.com/owl_posting Sergey's X: https://x.com/sokrypton Youtube: https://youtu.be/6_RFXNxy62c Spotify: https://open.spotify.com/episode/0wPs3rmp0zrfauqToozrcv?si=DCtRf-xQTPiVYwslo-b2rQ Apple Podcasts: https://podcasts.apple.com/us/podcast/what-could-alphafold-4-look-like-sergey-ovchinnikov-3/id1758545538?i=1000704927828 Transcript: https://www.owlposting.com/p/what-could-alphafold-4-look-like?open=false#%C2%A7transcript To those in the protein design space, Dr. Sergey Ovchinnikov is a very, very well-recognized name. A recent MIT professor (circa early 2024), he has played a part in a staggering number of recent innovations in the field: ColabFold , RFDiffusion , Bindcraft , automated design of soluble proxies of membrane proteins , elucidating what protein language models are learning , conformational sampling via Alphafold2 , and many more. Of course, all these papers were group efforts, but Sergey's name comes up astonishingly frequently! And even beyond the research that have come from his lab in the last few years, the co-evolution work he did during his PhD/fellowship also laid some of the groundwork for the original Alphafold paper , being cited twice in it. As a result, Sergey’s work has gained a reputation for being something that is worth reading. But nobody has ever interviewed him before! Which was shocking for someone who was so pivotally important for the field. So, obviously, I wanted to be the first one to do it. After an initial call, I took a train down to Boston, booked a studio, and chatted with him for a few hours, asking every question I could think of. We talk about his own journey into biology research, some issues he has with Alphafold3, what Alphafold4-and-beyond models may look like, what research he’d want to spend a hundred million…","meta_description":"X: https://x.com/owl_posting Sergey's X: https://x.com/sokrypton Youtube: https://youtu.be/6_RFXNxy62c Spotify: https://open.spotify.com/episode/0wPs3rmp0…","key_points":[],"chapters":[],"topics":[],"duration_seconds":7599,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/owl-posting-6974455/episodes/what-could-alphafold-4-look-like-sergey-ovchinnikov-ep-3/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/owl-posting-6974455/what-could-alphafold-4-look-like-sergey-ovchinnikov-ep-3.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}