{"podcast":{"title":"Owl Posting","slug":"owl-posting-6974455","podcast_index_feed_id":6974455,"rss_url":"https://api.substack.com/feed/podcast/2520497/s/139003.rss","website_url":"https://www.owlposting.com/s/podcast","image_url":"https://substackcdn.com/feed/podcast/2520497/s/139003/5c1267a7053a23eae4b2e6f61eab88e7.jpg","author":"Abhishaike Mahajan","episode_count":11,"summary":"Some audio-based content over biology-ML. Some of these are conversions of existing posts that lend itself well to audio.","last_synced_at":"2026-07-06T10:19:44.481952+00:00","page_url":"https://stenobird.com/podcast/owl-posting-6974455"},"episode":{"title":"Bringing organ-scale cryopreservation into existence (Hunter Davis, Ep #6)","slug":"bringing-organ-scale-cryopreservation-into-existence-hunter-davis-ep-6","published_at":"2025-11-24T14:56:44+00:00","page_url":"https://stenobird.com/podcast/owl-posting-6974455/bringing-organ-scale-cryopreservation-into-existence-hunter-davis-ep-6","show_page_url":"https://stenobird.com/podcast/owl-posting-6974455","url":"https://www.owlposting.com/p/bringing-organ-scale-cryopreservation","audio_url":"https://api.substack.com/feed/podcast/179772630/02354fdbe6cd25035835572eeffca499.mp3","summary":"Sponsor note: the supporter of this video is rush.cloud . If you are at all involved with doing preclinical drug discovery and would benefit from computational tools, you should check out their platform + beautiful website here: rush.cloud . If you’re at all interested in working together for future episodes, reach out! This is an interview with Hunter Davis , the CSO and co-founder (alongside Laura Deming ) of Until Labs , which you may also know by its prior name, Cradle. They are a biotech startup devoted to organ-scale cryopreservation. They raised a $58M Series A back in September 2025 , and are backed by Founders Fund (especially interesting!), Lux Ventures, and others. In this interview, we mainly talk about the engineering and scientific difficulties in the cryopreservation field, including some background details on their September 2024 progress report on neural slice rewarming , how they characterize tissue damage in their attempts to do kidney cryopreservation, the potential economics of future cryopreservation protocols, and lots more. One of the most interesting conversations I’ve had in a long time. If any of this work seems interesting , Until Labs is actively and aggressively hiring! Enjoy! Substack + Transcript: https://www.owlposting.com/p/bringing-organ-scale-cryopreservation Spotify: https://open.spotify.com/episode/23g2lR7dWl8NXUn893KMgv?si=5628cd0e56184130 Apple Podcasts: https://podcasts.apple.com/us/podcast/bringing-organ-scale-cryopreservation-into-existence/id1758545538?i=1000738128994 Youtube: https://youtu.be/xaqwPd3ujHg Timestamps: [00:01:50] Introduction [00:05:00] Why don’t we have reversible cryopreservation today? [00:07:05] Why is freezing necessary at all for preservation? [00:08:23] Let’s discuss cryoprotectant agents [00:14:09] Unti…","meta_description":"Sponsor note: the supporter of this video is rush.cloud . If you are at all involved with doing preclinical drug discovery and would benefit from computat…","key_points":[],"chapters":[],"topics":[],"duration_seconds":6891,"processing_state":"not_requested","actions":[{"name":"request_transcript","method":"POST","url":"https://stenobird.com/v1/public/podcasts/owl-posting-6974455/episodes/bringing-organ-scale-cryopreservation-into-existence-hunter-davis-ep-6/transcription-requests","description":"Idempotently request low-priority transcript generation for this episode."},{"name":"read_markdown","method":"GET","url":"https://stenobird.com/podcast/owl-posting-6974455/bringing-organ-scale-cryopreservation-into-existence-hunter-davis-ep-6.md","description":"Read the agent-friendly Markdown representation of this episode resource."}]}}